{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:03Z","timestamp":1787013783732,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,25]],"date-time":"2018-02-25T00:00:00Z","timestamp":1519516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2018,6]]},"abstract":"\n Objective<\/jats:title>\n \n Data on special education in offspring exposed to selective serotonin reuptake inhibitors (\n SSRI<\/jats:styled-content>\n s)\n in utero<\/jats:italic>\n are lacking. We examined associations of\n in utero<\/jats:italic>\n SSRI<\/jats:styled-content>\n exposure with special education needs and delayed elementary school start.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A population\u2010based case\u2010cohort study using Danish nationwide birth and prescription registry data from 2005 to 2008. Follow\u2010up ends during 2011\u20132015 to capture special education needs during and delayed entry to the first elementary school year. Cases were\n in utero<\/jats:italic>\n SSRI<\/jats:styled-content>\n \u2010exposed offspring. Cohort\u2010controls were\n SSRI<\/jats:styled-content>\n \u2010unexposed offspring of mothers previously on\n SSRI<\/jats:styled-content>\n s. We reported odds ratios (\n OR<\/jats:styled-content>\n s) and 95% confidence intervals (\n CI<\/jats:styled-content>\n s), adjusted for relevant potential confounders.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 117 475 first\u2010incident non\u2010multiple pregnancy births, 3314 were\n SSRI<\/jats:styled-content>\n \u2010exposed, and 3536 were unexposed. Among\n SSRI<\/jats:styled-content>\n \u2010exposed offspring, 3.2% (\n n<\/jats:italic>\n = 98) had special school needs vs. 2.4% (\n n<\/jats:italic>\n = 77) in unexposed offspring,\n P<\/jats:italic>\n \u2010value=0.048. Correspondingly, 12.3% (\n n<\/jats:italic>\n = 383) among\n SSRI<\/jats:styled-content>\n \u2010exposed children had delayed school entry vs. 9.4% (\n n<\/jats:italic>\n = 308) in unexposed offspring,\n P<\/jats:italic>\n \u2010value < 0.001. Adjusted\n OR<\/jats:styled-content>\n for the association with special school needs was 1.12 (95%\n CI<\/jats:styled-content>\n 0.82\u20131.55;\n P<\/jats:italic>\n \u2010value = 0.48) and 1.38 (95%\n CI<\/jats:styled-content>\n 0.90\u20132.13;\n P<\/jats:italic>\n \u2010value = 0.14) for exposure in all three trimesters. The corresponding adjusted\n OR<\/jats:styled-content>\n s for delayed school entry were 1.17 (95%\n CI<\/jats:styled-content>\n 0.99\u20131.38;\n P<\/jats:italic>\n \u2010value = 0.073) and 1.40 (95%\n CI<\/jats:styled-content>\n 1.11\u20131.76;\n P<\/jats:italic>\n \u2010value = 0.004).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In utero<\/jats:italic>\n SSRI<\/jats:styled-content>\n exposure in all three trimesters was associated with delayed elementary school start but not special education needs.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/acps.12867","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T01:05:25Z","timestamp":1519607125000},"page":"481-490","source":"Crossref","is-referenced-by-count":9,"title":["Exposure to selective serotonin reuptake inhibitors\n in utero<\/i>\n and early elementary school outcomes"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9629-8670","authenticated-orcid":false,"given":"K.","family":"Kragholm","sequence":"first","affiliation":[{"name":"Unit of Epidemiology and Biostatistics Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Cardiology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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F.","family":"Bech","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Polcwiartek","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Biostatistics Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Cardiology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9458-506X","authenticated-orcid":false,"given":"C.","family":"Rohde","sequence":"additional","affiliation":[{"name":"Mental Health Centre Copenhagen University Hospital Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Biostatistics Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Cardiology Aalborg 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