{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:52:38Z","timestamp":1792446758384,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R155\u20102014\u20101724"],"award-info":[{"award-number":["R155\u20102014\u20101724"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R165\u20102013\u201015320"],"award-info":[{"award-number":["R165\u20102013\u201015320"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002739","name":"Aarhus Universitets Forskningsfond","doi-asserted-by":"publisher","award":["AUFF\u2010E\u20102015\u2010FLS\u20107\u20102"],"award-info":[{"award-number":["AUFF\u2010E\u20102015\u2010FLS\u20107\u20102"]}],"id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2018,5]]},"abstract":"\n Objective<\/jats:title>\n \n Conversion from unipolar depression (\n UD<\/jats:styled-content>\n ) to bipolar disorder (\n BD<\/jats:styled-content>\n ) is a clinically important event that should lead to treatment modifications. Unfortunately, recognition of this transition is often delayed. Therefore, the objective of this study was to identify predictors of diagnostic conversion from\n UD<\/jats:styled-content>\n to\n BD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Historical prospective cohort study based on 91 587 individuals diagnosed with\n UD<\/jats:styled-content>\n in Danish hospital psychiatry between 1995 and 2016. The association between a series of potential predictors and the conversion from\n UD<\/jats:styled-content>\n to\n BD<\/jats:styled-content>\n during follow\u2010up (702 710 person\u2010years) was estimated by means of Cox regression with death as competing risk.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n During follow\u2010up, 3910 individuals with\n UD<\/jats:styled-content>\n developed\n BD<\/jats:styled-content>\n . The cumulative incidence of conversion was slightly higher in females (8.7%, 95%\n CI<\/jats:styled-content>\n : 8.2\u20139.3) compared to males (7.7%, 95%\n CI<\/jats:styled-content>\n : 7.0\u20138.4). The strongest predictor of conversion from\n UD<\/jats:styled-content>\n to\n BD<\/jats:styled-content>\n was parental history of\n BD<\/jats:styled-content>\n (adjusted hazard ratio (\n aHR<\/jats:styled-content>\n ) = 2.60, 95%\n CI<\/jats:styled-content>\n : 2.20\u20133.07)). Other predictors included psychotic depression at the index\n UD<\/jats:styled-content>\n episode (\n aHR<\/jats:styled-content>\n = 1.73, 95%\n CI<\/jats:styled-content>\n : 1.48\u20132.02), a prior\/concomitant non\u2010affective psychosis (\n aHR<\/jats:styled-content>\n = 1.73, 95%\n CI<\/jats:styled-content>\n : 1.51\u20131.99), and in\u2010patient treatment at the index episode (\n aHR<\/jats:styled-content>\n = 1.76, 95%\n CI<\/jats:styled-content>\n : 1.63\u20131.91).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Diagnostic conversion from\n UD<\/jats:styled-content>\n to\n BD<\/jats:styled-content>\n is predicted by severe depression requiring in\u2010patient treatment, psychotic symptomatology, and parental history of\n BD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/acps.12869","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T02:26:39Z","timestamp":1519957599000},"page":"422-432","source":"Crossref","is-referenced-by-count":76,"title":["Patterns and predictors of conversion to bipolar disorder in 91 587 individuals diagnosed with unipolar depression"],"prefix":"10.1111","volume":"137","author":[{"given":"K. L.","family":"Musliner","sequence":"first","affiliation":[{"name":"National Center for Register\u2010Based Research Department of Economics and Business Economics School of Business and Social Sciences Aarhus University Aarhus Denmark"},{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH Aarhus Denmark"},{"name":"CIRRAU\u2014Center for Integrated Register\u2010based Research at Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8032-6208","authenticated-orcid":false,"given":"S. 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