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We used nonparametric correlations to study the links between the MetS parameters, atherogenic index of plasma (<jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content>), sleep efficacy, sleep latency, fragmentation index, and phase and amplitude of rhythms. We performed multivariable analyses to take into account potential confounding factors such as sleep apnea risk, antipsychotics use, and smoker status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found correlations between lower sleep efficiency and higher triglyceride levels (<jats:italic>P<\/jats:italic>= 0.002), lower M10 onset (beginning of the 10 most active hours during the 24\u2010h cycle) and higher systolic blood pressure (<jats:italic>P<\/jats:italic>= 0.03), higher fragmentation index and higher systolic blood pressure (<jats:italic>P<\/jats:italic>= 0.009), lower sleep efficiency, higher fragmentation index, and higher<jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content>(respectively<jats:italic>P<\/jats:italic>= 0.02 and<jats:italic>P<\/jats:italic>= 0.04). These correlations mostly remained significant when adjusting for confounders, with the exception of M10 onset and systolic blood pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sleep efficiency and fragmentation index might contribute to the cardiovascular risk of patients with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>independently of major confounding factors. Although these associations did not imply causality, proposing interventions on sleep quality and circadian rhythm regularity might contribute to reduce cardiovascular risk in patients with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12910","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T08:45:52Z","timestamp":1527669952000},"page":"155-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Metabolic syndrome and actigraphy measures of sleep and circadian rhythms in bipolar disorders during remission"],"prefix":"10.1111","volume":"138","author":[{"given":"H.","family":"Brochard","sequence":"first","affiliation":[{"name":"P\u00f4le sectoriel Centre Hospitalier Fondation Vall\u00e9e Gentilly France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5004-5475","authenticated-orcid":false,"given":"O.","family":"Godin","sequence":"additional","affiliation":[{"name":"Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique (IPLESP UMRS 1136) Sorbonne Universit\u00e9s Universit\u00e9 Pierre et Marie Curie Paris France"},{"name":"INSERM UMR_S 1136 Paris France"},{"name":"Fondation FondaMental Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9121-209X","authenticated-orcid":false,"given":"P. 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