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This review evaluates treatment evidence for six common symptom targets in children\/adolescents with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and provides a resource to facilitate application of the evidence to clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A systematic search identified randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) and high\u2010quality systematic reviews published between 2007 and 2016, focused on: social interaction\/communication impairment, stereotypic\/repetitive behaviours, irritability\/agitation, attention\u2010deficit\/hyperactivity disorder symptoms, mood or anxiety symptoms, and sleep difficulties. We then completed qualitative evaluation of high\u2010quality systematic reviews\/meta\u2010analyses and quantitative evaluation of recently published <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s not covered by prior comprehensive systematic reviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recently published <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s focused on social interaction and communication impairment (trials\u00a0=\u00a032) using psychosocial interventions. Interventions for irritability\/agitation (trials\u00a0=\u00a016) were mainly pharmacological. Few <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s focused on other symptom targets (trials\u00a0=\u00a02\u20135\/target). Integration of these results with our qualitative review indicated that few established treatment modalities exist, and available evidence is limited by small studies with high risk of bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the current evidence\u2010base, treatment targets must be clearly defined, and a systematic approach to intervention trials in children\/adolescents with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> must be undertaken with careful consideration of the limitations of safety\/efficacy data.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12918","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T04:50:41Z","timestamp":1529038241000},"page":"379-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Systematic review and guide to management of core and psychiatric symptoms in youth with autism"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7282-6077","authenticated-orcid":false,"given":"S. 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