{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:06Z","timestamp":1787013786746,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      There is ongoing concern about the possible negative impact of\n                      <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>\n                      on neurocognitive functioning in older patients. In this study, we aimed to characterize the long\u2010term cognitive effects of\n                      <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>\n                      in patients with late\u2010life depression, using an extensive neuropsychological battery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 110 patients aged 55\u00a0years and older with unipolar depression, referred for\n                      <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>\n                      were included. The neuropsychological test battery was assessed prior to\n                      <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>\n                      and 6\u00a0months after the last\n                      <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>\n                      session.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no statistically significant group\u2010level changes from baseline to 6\u00a0months post\u2010\n                      <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>\n                      in any of the neuropsychological measurements. Individual differences in cognitive performance were detected using the Reliable Change Index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Patients with late\u2010life depression do not show deleterious cognitive effects 6\u00a0months following an\n                      <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>\n                      index course, although there are considerable differences at an individual level. Clinicians should not hesitate to prescribe\n                      <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>\n                      in older patients, as most of these patients will tolerate the treatment course and a small group will even experience a cognitive enhancement. However, clinicians should be aware that a small group of patients can experience cognitive side\u2010effects. Further study is needed to predict which patients have a higher risk of developing cognitive side\u2010effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.12942","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T02:01:09Z","timestamp":1531447269000},"page":"223-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Long\u2010term neurocognitive functioning after electroconvulsive therapy in patients with late\u2010life depression"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-1543","authenticated-orcid":false,"given":"J.","family":"Obbels","sequence":"first","affiliation":[{"name":"KU Leuven \u2013 University of Leuven University Psychiatric Center KU Leuven Academic Center for ECT and Neuromodulation (AcCENT) Kortenberg 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