{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:06:19Z","timestamp":1792112779784,"version":"4.4.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Treatment with most antipsychotics is associated with an increased risk of weight gain and metabolic disturbances. In a randomized trial, we previously demonstrated that 16\u00a0weeks of glucagon\u2010like peptide\u20101 receptor agonist liraglutide treatment vs. placebo significantly reduced glucometabolic disturbances and body weight in prediabetic, overweight\/obese schizophrenia\u2010spectrum disorder patients treated with clozapine or olanzapine. The aim of this study was to investigate whether the beneficial effects of the 16\u2010week intervention were sustained beyond the intervention period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>One year after completion of the intervention, we investigated changes in body weight, fasting glucose, glycated hemoglobin, C\u2010peptide, and lipids comparing 1\u2010year follow\u2010up levels to end of treatment (week 16) and baseline (week 0) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From end of treatment to the 1\u2010year follow\u2010up, body weight had increased in the liraglutide\u2010treated group. However, compared to baseline levels, the placebo\u2010subtracted body weight loss remained significantly reduced (\u22123.8\u00a0kg, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22127.3 to \u22120.2, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04). Fasting glucose, glycated hemoglobin, C\u2010peptide, and lipids had each returned to baseline levels 1\u00a0year after stopping liraglutide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The body weight reduction during 16\u00a0weeks of liraglutide treatment was partially sustained 1\u00a0year after the intervention was completed. However, the improvements in other metabolic parameters returned to baseline levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.12982","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T10:21:39Z","timestamp":1540894899000},"page":"26-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["One\u2010year follow\u2010up on liraglutide treatment for prediabetes and overweight\/obesity in clozapine\u2010 or olanzapine\u2010treated patients"],"prefix":"10.1111","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2339-6725","authenticated-orcid":false,"given":"C. K.","family":"Svensson","sequence":"first","affiliation":[{"name":"Psychiatric Centre Copenhagen Rigshospitalet Mental Health Services Capital Region of Denmark, Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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