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Meta\u2010analyses were performed when \u22652 studies examined the same potential predictor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 71 studies, including over 12\u00a0000 patients, identified six predictors of good response: mania\u2010depression\u2010interval sequence [odds ratio (OR): 4.27; 95% CI: 2.61, 6.97; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001], absence of rapid cycling (OR for rapid cycling: 0.30; 95% CI: 0.17, 0.53; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), absence of psychotic symptoms (OR for psychotic symptoms: 0.52; 95% CI: 0.34, 0.79; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), family history of bipolar disorder (OR: 1.61; 95% CI: 1.03, 2.52; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.036), shorter prelithium illness duration [standardised mean difference (SMD): \u22120.26; 95% CI: \u22120.41, \u22120.12; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001] and later age of onset (SMD: 0.17; 95% CI: 0.02, 0.36; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.029). Additionally, higher body mass index was associated with poor response in two studies (SMD: \u22120.61; 95% CI: \u22120.90, \u22120.32; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). There was weak evidence for number of episodes prior to lithium treatment (SMD: \u22120.42; 95% CI: \u22120.84, \u22120.01; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.046), number of hospitalisations before lithium (SMD: \u22120.40; 95% CI: \u22120.81, 0.01; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.055) and family history of lithium response (OR: 10.28; 95% CI: 0.66, 161.26; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.097).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The relative importance of these clinical characteristics should be interpreted with caution because of potential biases and confounding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13062","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T07:33:31Z","timestamp":1561016011000},"page":"94-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["A systematic review and meta\u2010analysis of clinical predictors of lithium response in bipolar disorder"],"prefix":"10.1111","volume":"140","author":[{"given":"T. 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