{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:36:53Z","timestamp":1787996213987,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["HEALTH\u2010F2\u20102010\u2010242114"],"award-info":[{"award-number":["HEALTH\u2010F2\u20102010\u2010242114"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Antipsychotic\u2010induced weight gain (Ai<jats:styled-content style=\"fixed-case\">WG<\/jats:styled-content>) is a debilitating adverse effect of most antipsychotics. First\u2010episode psychosis patients are particularly vulnerable to the detrimental consequences of Ai<jats:styled-content style=\"fixed-case\">WG<\/jats:styled-content>. Amisulpride has good efficacy and tolerability. We here aimed to identify the phenotypic factors associated with amisulpride\u2010induced weight gain in first\u2010episode psychosis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Data were collected from the Optimization of Treatment and Management of Schizophrenia in Europe trial. Multivariable regression models with various phenotypic variables (<jats:italic>N<\/jats:italic>\u00a0=\u00a0305) were performed with absolute Ai<jats:styled-content style=\"fixed-case\">WG<\/jats:styled-content> and clinically relevant Ai<jats:styled-content style=\"fixed-case\">WG<\/jats:styled-content> (\u22657% Ai<jats:styled-content style=\"fixed-case\">WG<\/jats:styled-content>) as outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four weeks of amisulpride treatment increased body weight from 69.7 to 72.4\u00a0kg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In the regression model of absolute Ai<jats:styled-content style=\"fixed-case\">WG<\/jats:styled-content>, unemployment (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.94, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016), younger age (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.07, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.031) and absence of current comorbid major depression disorder (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22121.61, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.034) were positively associated with absolute Ai<jats:styled-content style=\"fixed-case\">WG<\/jats:styled-content>. In the regression model of clinically relevant Ai<jats:styled-content style=\"fixed-case\">WG<\/jats:styled-content>, unemployment (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.83, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), schizophreniform disorder (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.00, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025) and low baseline weight (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.97, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.032) increased the likelihood of clinically relevant Ai<jats:styled-content style=\"fixed-case\">WG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinicians prescribing amisulpride should consider the relatively high susceptibility to Ai<jats:styled-content style=\"fixed-case\">WG<\/jats:styled-content> in unemployed first\u2010episode patients with psychosis, in particular young subjects with a diagnosis of schizophreniform disorder. We advise to carefully monitor these patients and, when needed, implement weight\u2010reducing strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13074","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T16:28:13Z","timestamp":1563553693000},"page":"283-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Phenotypic factors associated with amisulpride\u2010induced weight gain in first\u2010episode psychosis patients (from the <scp>OPT<\/scp>iMi<scp>SE<\/scp> cohort)"],"prefix":"10.1111","volume":"140","author":[{"given":"R.","family":"Pandit","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Cianci","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Research Support Julius Center for Health Sciences and Primary Care University Medical Center Utrecht University of Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E.","family":"ter Hark","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht University Utrecht the Netherlands"},{"name":"Department of Psychiatry Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Winter\u2010van Rossum","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2590-5055","authenticated-orcid":false,"given":"B. H.","family":"Ebdrup","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychiatric Schizophrenia Research CNSR &amp; Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS Mental Health Centre Glostrup Copenhagen University Hospital Glostrup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. V.","family":"Broberg","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychiatric Schizophrenia Research CNSR &amp; Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS Mental Health Centre Glostrup Copenhagen University Hospital Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-1622","authenticated-orcid":false,"given":"M. P.","family":"Garcia\u2010Portilla","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and CIBERSAM University of Oviedo Oviedo Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria del Principado de Asturias (ISPA) Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bobes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and CIBERSAM University of Oviedo Oviedo Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria del Principado de Asturias (ISPA) Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H.","family":"Vinkers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Amsterdam UMC (location VUmc) Amsterdam the Netherlands"},{"name":"Department of Anatomy and Neurosciences Amsterdam UMC (location VUmc) Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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