{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:08:55Z","timestamp":1773900535874,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G.0746.09"],"award-info":[{"award-number":["G.0746.09"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Electroconvulsive therapy (ECT)\u2010induced hippocampal volume change (HVC) has been repeatedly described in recent years. The similar time course of HVC and ECT\u2010related cognitive effects suggest a relation, that is to date, understudied. This study investigates whether HVC following ECT predicts the change in memory performance six months after the end of the ECT treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hippocampal volume (HV) was measured via high\u2010resolution 3D T1\u2010weighted images in 88 patients with late\u2010life depression, within 1\u00a0week before and after ECT. Memory performance was assessed before and six months after ECT. Multiple linear regression was used to examine whether change in memory performance could be predicted based on ECT\u2010induced changes in HV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Larger right absolute HVC predicts less pronounced improvement on the VAT (visual memory) in the whole sample. For the 8\u2010Word Test (verbal memory), Category Fluency Test (semantic memory), and MMSE, the effect is only present in patients who switched from right unilateral to bitemporal stimulation after six ECT sessions. Absolute HVC in the left hemisphere was not significantly related to cognitive change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A larger absolute change in right HV during ECT is associated with less improvement in memory performance up to 6\u00a0months post\u2010ECT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13086","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T10:39:15Z","timestamp":1565779155000},"page":"435-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Association between hippocampal volume change and change in memory following electroconvulsive therapy in late\u2010life depression"],"prefix":"10.1111","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3673-122X","authenticated-orcid":false,"given":"M.","family":"Laroy","sequence":"first","affiliation":[{"name":"KU Leuven \u2013 University of Leuven, Academic 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