{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:20:28Z","timestamp":1759033228058,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008397","name":"Velux Fonden","doi-asserted-by":"publisher","award":["31205"],"award-info":[{"award-number":["31205"]}],"id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["DFF\u20136110\u201000195"],"award-info":[{"award-number":["DFF\u20136110\u201000195"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["09\u2010063599","09\u2010069151"],"award-info":[{"award-number":["09\u2010063599","09\u2010069151"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the incidence of suicidal and violent behaviour following initiation of antidepressant medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Cohorts of 997\u00a0911 conscripts and 95\u00a0794 patients with a first\u2010time affective disorder were followed for purchase of antidepressant medication, suicide, suicide attempts and conviction for violent crime in Danish registries between 1997 through 2015. Incidence of outcomes was estimated for the first 28\u00a0days, 28\u2013365\u00a0days or later after initiation of antidepressants or study entry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 16.5% of conscripts and 73.7% of patients with affective disorders initiated antidepressant medication. Incidence of suicide was 3\u20134 times higher during the first 28\u00a0days after initiation compared to the rates in the following year in both cohorts. A similar trend was seen among the untreated patients with affective disorders, whereas suicide incidence was stable at a low level among conscripts not treated with antidepressants. Incidence of attempted suicide was highest during the 28\u00a0days before and after initiation of antidepressants, while rates of violent crime were similar before and after initiation. These trends in incidence were independent of class of antidepressant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher rates of suicidal behaviour in the weeks following initiation of antidepressant medication probably reflect disease severity and a delay in mood response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13097","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T15:09:26Z","timestamp":1567696166000},"page":"522-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Incidence of suicidal behaviour and violent crime following antidepressant medication: a Danish cohort study"],"prefix":"10.1111","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-220X","authenticated-orcid":false,"given":"M.","family":"Osler","sequence":"first","affiliation":[{"name":"Center for Clinical Research and Prevention Bispebjerg and Frederiksberg Hospitals Copenhagen Denmark"},{"name":"Section for Epidemiology Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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B.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Psychiatric Centre Copenhagen Dept O Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Rozing","sequence":"additional","affiliation":[{"name":"Section for Epidemiology Department of Public Health University of Copenhagen Copenhagen Denmark"},{"name":"Psychiatric Centre Copenhagen Dept O Rigshospitalet Copenhagen Denmark"},{"name":"The Research Unit for General Practice and Section of General Practice Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32802-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1676-z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1951"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1022-x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11126-015-9389-8"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2880"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.081514"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2013.301680"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.10.979"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.6.840"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i65"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015337"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0213"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.09.029"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h517"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.150839"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0120-8"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001875"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2016-207265"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy048"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_11_23_1","first-page":"798","article-title":"Data resource profile: the Danish National Prescription Registry","volume":"46","author":"Pottegard A","year":"2017","journal-title":"Int J Epidem"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/08039480510027706"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203241"},{"key":"e_1_2_11_26_1","first-page":"17m11845","article-title":"Incidence of, risk factors for, and changes over time in treatment\u2010resistant depression in Denmark. 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