{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:21:07Z","timestamp":1792272067547,"version":"4.4.0"},"reference-count":140,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this meta\u2010analysis was to better understand the magnitude and consistency of the association between childhood adversity and borderline personality disorder (BPD) across case\u2013control, epidemiological and prospective cohort studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Following the review protocol (reference: CRD42017075179), search terms pertaining to adversity and BPD were entered into three search engines. Random\u2010effects meta\u2010analysis synthesised the size and consistency of the effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 97 studies compared BPD to non\u2010clinical (\n                      <jats:italic>k<\/jats:italic>\n                      \u00a0=\u00a040) and clinical (\n                      <jats:italic>k<\/jats:italic>\n                      \u00a0=\u00a070) controls. Meta\u2010analysis of case\u2013control studies indicated that individuals with BPD are 13.91 (95% CI 11.11\u201317.43) times more likely to report childhood adversity than non\u2010clinical controls. This effect was smaller when considering retrospective cohort (OR: 2.59; 95% CI 0.93\u20137.30) and epidemiological (OR: 2.56, 95% CI 1.24\u20135.30) studies. Findings were significant across adversity subtypes with emotional abuse (OR: 38.11, 95% CI: 25.99\u201355.88) and neglect (OR: 17.73, 95% CI\u00a0=\u00a013.01\u201324.17) demonstrating the largest effects. Individuals with BPD were 3.15 (95% CI 2.62\u20133.79) times more likely to report childhood adversity than other psychiatric groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta\u2010analysis corroborates theoretical proposals that exposure to adverse life experiences is associated with BPD. It highlights the importance of considering childhood adversity when treating people diagnosed with BPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13118","type":"journal-article","created":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T22:04:56Z","timestamp":1571522696000},"page":"6-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":384,"title":["Childhood adversity and borderline personality disorder: a meta\u2010analysis"],"prefix":"10.1111","volume":"141","author":[{"given":"C.","family":"Porter","sequence":"first","affiliation":[{"name":"Division of Psychology and Mental Health Faculty of Biology, Medicine and Health The University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Palmier\u2010Claus","sequence":"additional","affiliation":[{"name":"Spectrum Centre for Mental Health Research Division of Health Research Lancaster University 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