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Here, we aimed to conduct a meta\u2010analysis and meta\u2010regression study about the comorbidity and covariates of AD and PBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We systematically searched relevant articles published until May 2019, as defined in PRISMA guidelines. Variables for associated features and prevalence of AD were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven articles represented data for the analysis. Lifetime any AD comorbidity was 44.7%; panic disorder (PD) was 12.7%; generalized anxiety disorder (GAD) was 27.4%; social phobia was 20.1%; separation anxiety disorder (SAD) was 26.1%; and obsessive\u2013compulsive disorder (OCD) was 16.7%. Childhood\u2010onset studies reported higher GAD and SAD comorbidity, while adolescent\u2010onset studies reported higher PD, OCD, and social phobia. Age of onset, gender, comorbidity of ADHD, substance use, oppositional defiant disorder and conduct disorder affected each anxiety disorders\u2019 comorbidity with PBD differently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anxiety disorders are highly comorbid with PBD. Early\u2010onset PBD increases the risk of AD. Biopsychosocial aspects of this comorbidity and its course needs to be evaluated further.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13146","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T11:06:05Z","timestamp":1578049565000},"page":"327-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Anxiety disorders comorbidity in pediatric bipolar disorder: a meta\u2010analysis and meta\u2010regression study"],"prefix":"10.1111","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0318-2770","authenticated-orcid":false,"given":"H.","family":"Yap\u0131c\u0131 Eser","sequence":"first","affiliation":[{"name":"School of Medicine Department of Psychiatry Ko\u00e7 University \u0130stanbul Turkey"},{"name":"Research Center for Translational Medicine Ko\u00e7 University \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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