{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:32:07Z","timestamp":1780493527727,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T00:00:00Z","timestamp":1582934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","award":["SPHeRE\/2013\/1"],"award-info":[{"award-number":["SPHeRE\/2013\/1"]}],"id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the association between preeclampsia and attention\u2010deficit hyperactivity disorder (ADHD), using a large Swedish\u2010based registry cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study comprised 2\u00a0047\u00a0619 children, with 114\u00a0934 (5.6%) cases of ADHD. Preeclampsia was based on two alternate definitions: (i) preeclampsia (using ICD\u20109\/ICD\u201010) and (ii) preeclampsia and small for gestational age (SGA) combined. ADHD was determined in one of two ways: (i) if a diagnosis of ADHD was present in the National Patient Register or (ii) if an individual was in receipt of ADHD medication in the Prescribed Drug Register. Multivariate Cox proportional hazards regression analysis allowed adjustment for several perinatal\/sociodemographic factors. Sibling\u2010matched analysis further controlled for shared genetic and familial confounding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the adjusted Cox model, preeclampsia was associated with an increase in likelihood of ADHD (HR: 1.15, 95% CI: 1.12, 1.19). The HR for preeclampsia and those born SGA was 1.43 (95% CI: 1.31, 1.55) in the adjusted model, compared to those unexposed to preeclampsia\/SGA. The sibling\u2010matched analysis did not materially change these associations (HR: 1.13, 95% CI: 1.05, 1.22) and 1.55 (95% CI: 1.28, 1.88).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Exposure to preeclampsia or preeclampsia\/SGA was associated with ADHD, independent of genetic\/familial factors shared by siblings. However, it is important to note that sibling\u2010matched analysis can only adjust for factors that are constant between pregnancies; therefore, residual confounding cannot be ruled out. Further research is needed to explore modifiable risk factors and identify those most\u2010at\u2010risk babies following delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13162","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T07:40:58Z","timestamp":1581666058000},"page":"275-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Association between preeclampsia and attention\u2010deficit hyperactivity disorder: a population\u2010based and sibling\u2010matched cohort study"],"prefix":"10.1111","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6722-0484","authenticated-orcid":false,"given":"G. M.","family":"Maher","sequence":"first","affiliation":[{"name":"INFANT Research Centre Cork Ireland"},{"name":"School of Public Health University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dalman","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Division of Public Health Epidemiology Karolinska Institutet Stockholm Sweden"},{"name":"Center for Epidemiology and Community Medicine Stockholm County Council Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. W.","family":"O\u2019Keeffe","sequence":"additional","affiliation":[{"name":"INFANT Research Centre Cork Ireland"},{"name":"Department of Anatomy and Neuroscience University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Kearney","sequence":"additional","affiliation":[{"name":"School of Public Health University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. P.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"INFANT Research Centre Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. C.","family":"Kenny","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Institute of Translational Medicine Faculty of Health and Life Sciences University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Khashan","sequence":"additional","affiliation":[{"name":"INFANT Research Centre Cork Ireland"},{"name":"School of Public Health University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313276"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.05.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.6.942"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt261"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0070-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.0854"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.12.123"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1298"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-009-9350-y"},{"key":"e_1_2_11_11_1","unstructured":"National Board of Health and Welfare (Socialstyrelsen).In English \u2013 the Swedish Medical Birth Register;2019. 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