{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:03:01Z","timestamp":1787166181822,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST\u2010103\u20102314\u2010B\u2010280\u2010001\u2010MY3"],"award-info":[{"award-number":["MOST\u2010103\u20102314\u2010B\u2010280\u2010001\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Electroconvulsive therapy (ECT) is commonly used to treat patients with treatment\u2010resistant depression. We aimed to investigate whether combining an antidepressant agent with ECT might enhance therapeutic efficacy and prevent early relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      During the acute ECT phase, patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a097) with treatment\u2010resistant depression were randomized to receive ECT plus agomelatine 50\u00a0mg\/day (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a048) or ECT plus placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a049). Symptom severity measures, including the 17\u2010item Hamilton Depression Rating Scale (HAMD\u201017) and other scales, functional impairment, quality of life, neuropsychological tests, adverse events and attitudes toward ECT, were assessed regularly. Remission was defined as a HAMD\u201017 score \u22647. If patients achieved post\u2010ECT remission, they were prescribed agomelatine 50\u00a0mg\/day and participated in a 12\u2010week follow\u2010up trial. HAMD\u201017 was rated at 4\u2010week intervals. Relapse was defined as a HAMD\u201017 score \u226514, or rehospitalization for a psychiatric reason.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The two treatment groups were comparable at (i) baseline variables; (ii) score changes in all symptom measures, functional impairment, quality of life, and neuropsychological tests; (iii) frequency of adverse events and attitudes toward ECT; and (iv) post\u2010ECT response\/remission rates. There were no statistically significant differences following ECT in relapse rates and time to relapse between these two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adding agomelatine to ECT yielded comparable response\/remission rates to ECT without agomelatine in the acute ECT phase. Starting agomelatine in combination with ECT did not seem to be more efficacious in preventing relapse than starting agomelatine after the acute ECT course. More research is needed to guide clinical recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13183","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T19:55:42Z","timestamp":1589572542000},"page":"121-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of the efficacy of electroconvulsive therapy (ECT) plus agomelatine to ECT plus placebo in treatment\u2010resistant depression"],"prefix":"10.1111","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2744-0914","authenticated-orcid":false,"given":"C.\u2010H.","family":"Lin","sequence":"first","affiliation":[{"name":"Kaohsiung Municipal Kai\u2010Syuan Psychiatric Hospital Kaohsiung Taiwan"},{"name":"Department of Psychiatry School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.\u2010C.","family":"Yang","sequence":"additional","affiliation":[{"name":"Kaohsiung Municipal Kai\u2010Syuan Psychiatric Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010C.","family":"Chen","sequence":"additional","affiliation":[{"name":"Kaohsiung Municipal Kai\u2010Syuan Psychiatric Hospital Kaohsiung Taiwan"},{"name":"Department of Psychiatry School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.\u2010R.","family":"Cai","sequence":"additional","affiliation":[{"name":"Kaohsiung Municipal Kai\u2010Syuan Psychiatric Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Depression and other common mental disorders: global health 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