{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:08:18Z","timestamp":1790712498342,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GL1731"],"award-info":[{"award-number":["01GL1731"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["179185"],"award-info":[{"award-number":["179185"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Symptoms of insomnia are highly prevalent in the elderly. A significant number of pharmacological and non\u2010pharmacological interventions exist, but, up\u2010to\u2010date, their comparative efficacy and safety has not been sufficiently assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We integrated the randomized evidence from every available treatment for insomnia in the elderly (&gt;65\u00a0years) by performing a network meta\u2010analysis. Several electronic databases were searched up to May 25, 2019. The two primary outcomes were total sleep time and sleep quality. Data for other 6 efficacy and 8 safety outcomes were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010three RCTs with 6832 participants (75\u00a0years old on average) were included, 43 of which examined the efficacy of one or more drugs. Ten RCTs examined the efficacy of non\u2010pharmacological interventions and were evaluated only with pairwise meta\u2010analyses because they were disconnected from the network. The overall confidence in the evidence was very low primarily due to the small amount of data per comparison and their sparse connectedness. Several benzodiazepines, antidepressants, and z\u2010drugs performed better in both primary outcomes, but few comparisons had data from more than one trial. The limited evidence on non\u2010pharmacological interventions suggested that acupressure, auricular acupuncture, mindfulness\u2010based stress reduction program, and tart cherry juice were better than their control interventions. Regarding safety, no clear differences were detected among interventions due to large uncertainty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Insufficient evidence exists on which intervention is more efficacious for elderly patients with insomnia. More RCTs, with longer duration, making more direct interventions among active treatments and presenting more outcomes are urgently needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13201","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T15:17:29Z","timestamp":1591802249000},"page":"6-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Efficacy, acceptability, and tolerability of all available treatments for insomnia in the elderly: a systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6943-5091","authenticated-orcid":false,"given":"M. T.","family":"Samara","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy School of Medicine Klinikum rechts der Isar Technical University of Munich Munich Germany"},{"name":"3rd Department of Psychiatry School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Huhn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy School of Medicine Klinikum rechts der Isar Technical University of Munich Munich Germany"},{"name":"Department of Psychiatry, Psychosomatic Medicine and Psychotherapy Social Foundation Bamberg Teaching Hospital of the University of Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Chiocchia","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine (ISPM) University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schneider\u2010Thoma","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy School of Medicine Klinikum rechts der Isar Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wiegand","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy School of Medicine Klinikum rechts der Isar Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Salanti","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine (ISPM) University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Leucht","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy School of Medicine Klinikum rechts der Isar Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-010-9154-6"},{"key":"e_1_2_10_3_1","first-page":"1049","article-title":"National Institutes of Health State of the Science Conference statement on Manifestations and Management of Chronic Insomnia in Adults, June 13\u201015, 2005","volume":"28","author":"National Institutes of H","year":"2005","journal-title":"Sleep"},{"key":"e_1_2_10_4_1","first-page":"229","article-title":"The relationship between insomnia and health\u2010related quality of life in patients with chronic illness","volume":"51","author":"Katz DA","year":"2002","journal-title":"J Family Pract"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.01.011"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00072-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.863"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.07.050"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.8.986"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.02.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/25.6.621"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.3.263"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-47186-9_26"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200317110-00004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00571.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000136845.24802.19"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5742"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2008.06.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7172"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/0003495-200868170-00001"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.25.1.3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38623.768588.47"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02599201"},{"key":"e_1_2_10_24_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0","author":"Higgins JPT","year":"2011"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(00)00065-4"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.1992.tb00006.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198807000-00007"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.1.140"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00129-0"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117"},{"key":"e_1_2_10_33_1","unstructured":"R\u00bcckerG KrahnU K\u00f6nigJ EfthimiouO SchwarzerG.netmeta: Network Meta\u2010Analysis using Frequentist Methods 2020. Available from:https:\/\/github.com\/guido\u2010s\/netmetahttp:\/\/meta\u2010analysis\u2010with\u2010r.org."},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3767"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1044"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1045"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.05.027"},{"key":"e_1_2_10_38_1","volume-title":"Cochrane handbook for systematic reviews of interventions, Reprinted","author":"Higgins J","year":"2011"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099682"},{"key":"e_1_2_10_40_1","unstructured":"CINeMA: Confidence in Network Meta\u2010Analysis [Software]. Institute of Social and Preventive Medicine University of Bern;2017[updated 2017; cited]; Available from:cinema.ispm.unibe.ch."},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03232.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.06.010"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e8343"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-014-0198-7"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2016.07.016"},{"key":"e_1_2_10_47_1","first-page":"2","article-title":"The elderly patient\u2013who is that?","volume":"48","author":"Sieber CC","year":"2007","journal-title":"Der Internist"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31135-3"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6470"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-2175"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facps.13201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acps.13201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13201","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:38:31Z","timestamp":1693813111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.13201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/acps.13201"],"URL":"https:\/\/doi.org\/10.1111\/acps.13201","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ACPS.13201\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13201\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13201\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13201\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13201\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13201\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13201\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13201\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13201\/v3\/response1","asserted-by":"object"}]},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,30]]},"assertion":[{"value":"2020-05-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}