{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:14:25Z","timestamp":1791357265326,"version":"4.3.1"},"reference-count":183,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this paper, we aimed at reviewing evidence\u2010based treatment options for bipolar mania and proposed tentative evidence\u2010based clinical suggestions regarding the management of a manic episode, especially regarding the choice of the proper mood stabilizer and antipsychotic medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A narrative review was undertaken addressing 'treatment of bipolar mania'. Findings have been synthesized and incorporated with clinical experience into a model to support different treatment choices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>To date, there is solid evidence supporting the use of several medications, such as lithium, divalproex, and carbamazepine, and antipsychotics, such as chlorpromazine, haloperidol, risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, inhaled loxapine, asenapine, and cariprazine in acute mania, and some evidence supporting the use of clozapine or electroconvulsive therapy in treatment\u2010refractory cases. However, in clinical practice, when making decisions about treatment, personalized treatment is needed, according to the different clinical presentations and more complex clinical situations within the manic episode and considering a long\u2010term view and with the objective of not only a symptomatic but also functional recovery. After remission from acute mania, psychoeducation strategies are useful to ensure adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Despite the evidence forefficacy of many currently available treatments for mania, the majority of RCTs provide little direction for the clinician as to what steps might be optimal in different presentations of mania as well as in the presence of specific patient characteristics. Manic episodes should be managed on a personalized basis considering the clinical course and patient criteria and with the expectation of maintaining that treatment in the long\u2010term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13209","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T15:45:37Z","timestamp":1594395937000},"page":"173-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["How to treat mania"],"prefix":"10.1111","volume":"142","author":[{"given":"I.","family":"Pacchiarotti","sequence":"first","affiliation":[{"name":"Bipolar and Depressive Disorders Unit Institute of Neuroscience Hospital Clinic IDIBAPS CIBERSAM University of Barcelona 170 Villarroel st, 12\u20100 Barcelona Catalonia 08036 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6798-4054","authenticated-orcid":false,"given":"G.","family":"Anmella","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit Institute of Neuroscience Hospital Clinic IDIBAPS CIBERSAM University of Barcelona 170 Villarroel st, 12\u20100 Barcelona Catalonia 08036 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9964-0822","authenticated-orcid":false,"given":"L.","family":"Colomer","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit Institute of Neuroscience Hospital Clinic IDIBAPS CIBERSAM University of Barcelona 170 Villarroel st, 12\u20100 Barcelona Catalonia 08036 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-0053","authenticated-orcid":false,"given":"E.","family":"Vieta","sequence":"additional","affiliation":[{"name":"Bipolar and Depressive Disorders Unit Institute of Neuroscience Hospital Clinic IDIBAPS CIBERSAM University of Barcelona 170 Villarroel st, 12\u20100 Barcelona Catalonia 08036 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2008.10.2\/evieta"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12423"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145703003341"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00241-X"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12609"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12813"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0044-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116636545"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852916000845"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2015.52"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00139-X"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2051-5545.2011.tb00037.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1101370"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2018.10.001"},{"key":"e_1_2_11_18_1","unstructured":"NICE.Bipolar Disorder the Nice Guideline on the Assessment and Management of Bipolar Disorder in Adults Children and Young People in Primary and Secondary Care Updated Edition. National Collaborating Centre for Mental Health 2014.http:\/\/www.nice.org.uk\/guidance\/CG185"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S82532"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2535"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2011.9.6864"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415617657"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2013.770551"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyw109"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2015.1132007"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2011.00975.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2011.02890.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-017-1490-0"},{"key":"e_1_2_11_29_1","article-title":"Personalized medicine begins with the phenotype: identifying antipsychotic response phenotypes in a first\u2010episode psychosis cohort","author":"Mas S","year":"2019","journal-title":"Acta Psychiatr Scand"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-908517-94-4"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13020185"},{"issue":"5","key":"e_1_2_11_32_1","first-page":"9","article-title":"Monotherapy versus combined treatment with second\u2010generation antipsychotics in bipolar disorder","volume":"69","author":"Ketter TA","year":"2008","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714001305"},{"key":"e_1_2_11_34_1","first-page":"13","article-title":"Key treatment studies of lithium in manic\u2010depressive illness: Efficacy and side effects","volume":"59","author":"Bowden CL","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830130041008"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00390-6"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.00990.x"},{"key":"e_1_2_11_38_1","article-title":"Treatment of mania, mixed state, and rapid cycling","volume":"42","author":"Kusumakar V","year":"1997","journal-title":"Can J Psychiatry"},{"key":"e_1_2_11_39_1","first-page":"277","article-title":"Prediction of treatment response in acute mania: controlled clinical trials with divalproex","volume":"27","author":"Swann AC","year":"2001","journal-title":"Encephale"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2006.00344.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12543"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-019-0151-2"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.138685"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12805"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyw100"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-014-0197-8"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200620010-00003"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12017"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-014-0014-9"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415614109"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000148"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2015.1012225"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145713001168"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.07.038"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068020"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488611798918656"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.6.806"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800320037004"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.6.759"},{"key":"e_1_2_11_60_1","first-page":"91","article-title":". Clozapine in treatment\u2010refractory mood disorders","author":"Kimmel SE","year":"1994","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199703000-00006"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12272"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31135-3"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S227196"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30081-5"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.10.015"},{"key":"e_1_2_11_67_1","unstructured":"StahlSM.Stahl\u2019s essential psychopharmacology: neuroscientific basis and practical application 2013."},{"key":"e_1_2_11_68_1","unstructured":"The Royal College of Psychiatrists.PS04\/18. Withdrawal of and alternatives to valproate\u2010containing medicines in girls and women of childbearing potential who have a psychiatric illness 2018.https:\/\/www.bap.org.uk\/pdfs\/PS04\u201018\u2010December2018.pdf"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.09.007"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2009.01.005"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.1999.10106.x"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(14)70314-1"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.158"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n1003"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0414"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.01.047"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.06.008"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.06.013"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.040485"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx032"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12871"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12894"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.02.003"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.16m11201"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.01.015"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00761.x"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-019-00629-z"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2015.0091"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.9.1636"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.01.022"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0805"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04994yel"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13014"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12949"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2011.02.007"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00139.x"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(05)70100-3"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988712436683"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15010124"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000659"},{"key":"e_1_2_11_101_1","unstructured":"European Medicines Agency.EMA\/33617\/2014 \u2013 Rev. 3. Questions & answers on Article 31 pharmacovigilance referral procedures 2019.www.ema.europa.eu\/contact"},{"key":"e_1_2_11_102_1","unstructured":"NICE.Antenatal and postnatal mental health: Antenatal and postnatal mental health: clinical management and service clinical management and service guidance Clinical guideline. National Collaborating Centre for Mental Health 2014.https\/\/www.nice.org.uk\/guidance\/cg192\/resources\/antenatal\u2010and\u2010postnatal\u2010mental\u2010health\u2010clinical\u2010management\u2010and\u2010service\u2010guidance\u2010pdf\u201035109869806789."},{"key":"e_1_2_11_103_1","unstructured":"AEMPS. VALPROATO: PROGRAMA DE PREVENCI\u00d3N DE EMBARAZOS.Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios (AEMPS) 2018.www.notificaRAM.es"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00197-4"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612222"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19030228"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12479"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2012.10.001"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60873-8"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn107"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.2147\/DHPS.S50556"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.1520"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-018-0517-5"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1080\/00048670701732723"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001002"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.776"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-92919-4_2"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-007-0433-2"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.09.008"},{"key":"e_1_2_11_120_1","first-page":"9","article-title":"Neuropsychiatric Disease and Treatment A critical review of the recent literature and selected therapy guidelines since on the use of lamotrigine in bipolar disorder","volume":"2013","author":"Tr\u00e4nkner A","year":"2006","journal-title":"Neuropsychiatr Dis Treat"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b13e318033bd5e"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1260"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200108000-00006"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-6757(02)42249-8"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-44462011000100008"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2010.04.005"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.07.005"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1159\/000315437"},{"key":"e_1_2_11_129_1","article-title":"Adjunctive treatment of manic agitation with lorazepam versus haloperidol: a double\u2010blind study","author":"Lenox RH","year":"1992","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12262"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0315"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.09.007"},{"key":"e_1_2_11_133_1","volume-title":"Manic\u2010depressive illness: bipolar disorders and recurrent depression","author":"Goodwin FK","year":"2007"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00024-5"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.182.2.141"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2004.06.003"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.6.1057"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2019.10.006"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415585583"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.03.007"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.12.019"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852916000845"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12896"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852917000013"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.04.032"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711001817"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f3646"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2012.01882.x"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.6.956"},{"key":"e_1_2_11_150_1","unstructured":"StahlSM.Stahl's essential psychopharmacology: neuroscientific basis and practical application 2013."},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/55.10.1003"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09r05815gre"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.03.035"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.01.032"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01818.x"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13r08905"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12288"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.08.059"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12045"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.11.2152"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707000864"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.2.242"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2539"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12045"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20252"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.5.543"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00641"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12667"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00377-9"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2011.00889.x"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.09.009"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.116.186833"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.11.1841"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086320"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12581"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.10.001"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20441"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2015.03.003"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17090972"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.31"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20351"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.2174\/1745017901107010112"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867411432072"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2017-3902"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facps.13209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acps.13209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T03:22:49Z","timestamp":1693711369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.13209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,3]]},"references-count":183,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/acps.13209"],"URL":"https:\/\/doi.org\/10.1111\/acps.13209","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ACPS.13209\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13209\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13209\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13209\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13209\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13209\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13209\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13209\/v2\/review1","asserted-by":"object"}]},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,3]]},"assertion":[{"value":"2020-06-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}