{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:31:45Z","timestamp":1791923505664,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIAMH002927"],"award-info":[{"award-number":["ZIAMH002927"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["NCT0088699"],"award-info":[{"award-number":["NCT0088699"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Ketamine's effects on different dimensions of depressive symptomatology, including typical\/melancholic and atypical depression, remain largely unknown. This study examined the effects of a single intravenous dose of ketamine on general depressive symptoms (measured using the Montgomery\u2013Asberg Depression Rating Scale (MADRS), typical\/melancholic symptoms (measured using the MADRS5), and atypical symptoms (measured using the Scale for Atypical Symptoms (SAS)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from 68 participants with treatment\u2010resistant major depressive disorder (MDD) or bipolar depression were pooled from three separate, double\u2010blind, placebo\u2010controlled, crossover studies investigating ketamine's efficacy in depression. MDD participants were unmedicated; bipolar participants received therapeutic\u2010dose lithium or valproate. Clinical symptoms were collected preinfusion and up to 14\u00a0days postinfusion. Effect sizes were calculated for days 1 and 3 postinfusion. The primary measures of interest for this exploratory analysis were total MADRS, MADRS5, and SAS scores. Individual symptoms were also analyzed in an exploratory manner.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Scores improved significantly at Day 1 postinfusion (MADRS: Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.64; MADRS5: Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.61; SAS: Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.41) and continued to be significantly improved over placebo at Day 3 (MADRS: Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.49; MADRS5: Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.43; SAS: Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      \u00a0=\u00a00.39). Effect sizes were greater for typical\/melancholic than atypical symptoms at Day 1 postinfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ketamine appears to effectively treat both the typical\/melancholic and atypical symptoms of depression, but may have early preferential effects for the former.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13216","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:04:13Z","timestamp":1594944253000},"page":"394-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The effects of ketamine on typical and atypical depressive symptoms"],"prefix":"10.1111","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-686X","authenticated-orcid":false,"given":"L. T.","family":"Park","sequence":"first","affiliation":[{"name":"Section on the Neurobiology and Treatment of Mood Disorders National Institute of Mental Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Luckenbaugh","sequence":"additional","affiliation":[{"name":"Section on the Neurobiology and Treatment of Mood Disorders National Institute of Mental Health Bethesda MD USA"},{"name":"Equity, Diversity, and Inclusion Office of the Director National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Pennybaker","sequence":"additional","affiliation":[{"name":"Section on the Neurobiology and Treatment of Mood Disorders National Institute of Mental Health Bethesda MD USA"},{"name":"University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Section on the Neurobiology and Treatment of Mood Disorders National Institute of Mental Health Bethesda MD USA"},{"name":"Department of Psychiatry Georgetown University Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. D.","family":"Henter","sequence":"additional","affiliation":[{"name":"Section on the Neurobiology and Treatment of Mood Disorders National Institute of Mental Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Lener","sequence":"additional","affiliation":[{"name":"Section on the Neurobiology and Treatment of Mood Disorders National Institute of Mental Health Bethesda MD USA"},{"name":"Singula Institute New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kadriu","sequence":"additional","affiliation":[{"name":"Section on the Neurobiology and Treatment of Mood Disorders National Institute of Mental Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. D.","family":"Ballard","sequence":"additional","affiliation":[{"name":"Section on the Neurobiology and Treatment of Mood Disorders National Institute of Mental Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"C. A.","family":"Zarate","sequence":"additional","affiliation":[{"name":"Section on the Neurobiology and Treatment of Mood Disorders National Institute of Mental Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1996.tb09884.x"},{"issue":"18","key":"e_1_2_10_3_1","first-page":"5","article-title":"Course and treatment of atypical depression","volume":"59","author":"Nierenberg AA","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5136.1491"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(60)73041-X"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00169-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.0307e08"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.05.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0807"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.144"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05398blu"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-6-1382"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.10.023"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.3016"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2007.00965.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2006.8.2\/fbenazzi"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716000064"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13096"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.90"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.12.010"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0028-2"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.03.024"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.02.005"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facps.13216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acps.13216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T10:21:46Z","timestamp":1693736506000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.13216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/acps.13216"],"URL":"https:\/\/doi.org\/10.1111\/acps.13216","archive":["Portico"],"relation":{},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,6]]},"assertion":[{"value":"2020-07-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}