{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:54:17Z","timestamp":1774608857639,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR PJT\u2010156021"],"award-info":[{"award-number":["CIHR PJT\u2010156021"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to compare the risk for injury overall and by intent (accidental injury, self\u2010injury, and assault) among children born to women with versus without schizophrenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using health administrative data from Ontario, Canada, children born from 2003 to 2017 to mothers with (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03769) and without (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01,830,054) schizophrenia diagnosed prior to their birth were compared on their risk for child injury, captured via emergency department, hospitalization, and vital statistics databases up to age 15\u00a0years. Cox proportional hazard models generated hazard ratios for time to first injury event (overall and by intent), adjusted for potential confounders (aHR). We stratified by child sex and age at follow\u2010up: 0\u20131 (infancy), 2\u20135 (pre\u2010school), 6\u20139 (primary school), and 10\u201315 (early adolescence) planning to collapse age categories as needed to obtain stable and reportable estimates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Maternal schizophrenia was associated with elevated risk for child injury overall (105.4 vs. 89.4\/1000 person\u2010years (py), aHR 1.08, 95% CI 1.03\u20131.14), accidental injury (104.7 vs. 88.1\/1000py, 1.08, 1.03\u20131.14), for self\u2010injury (0.4 vs. 0.2\/1000py, 2.14 1.18\u20133.85), and assault (1.0 vs. 0.3\/1000py, 2.29, 1.45\u20133.62). By child sex, point estimates were of similar magnitude and direction, though not all remained statistically significant. For accidental injury and self\u2010injury, the risk associated with maternal schizophrenia was most elevated in 10\u201315\u2010year\u2010olds. For assault, the risk associated with maternal schizophrenia was most elevated among children in the 0\u20131 and 2\u20135\u2010year\u2010old age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The elevated risk of child injury associated with maternal schizophrenia, especially for self\u2010injury and assault, suggests that targeted monitoring and preventive interventions are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13281","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T12:53:11Z","timestamp":1611751991000},"page":"406-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Accidental injury, self\u2010injury, and assault among children of women with schizophrenia: a population\u2010based cohort study"],"prefix":"10.1111","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-1400","authenticated-orcid":false,"given":"Clare L.","family":"Taylor","sequence":"first","affiliation":[{"name":"Women\u2019s College Research Institute Women\u2019s College Hospital Toronto ON Canada"},{"name":"ICES Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8690-5841","authenticated-orcid":false,"given":"Hilary K.","family":"Brown","sequence":"additional","affiliation":[{"name":"Women\u2019s College Research Institute Women\u2019s College Hospital Toronto ON Canada"},{"name":"ICES Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto Toronto ON Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto ON Canada"},{"name":"Interdisciplinary Centre for Health &amp; Society University of Toronto Scarborough ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha R.","family":"Saunders","sequence":"additional","affiliation":[{"name":"ICES Toronto ON Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto ON Canada"},{"name":"The Hospital for Sick Children Toronto ON Canada"},{"name":"Department of Paediatrics University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy C.","family":"Barker","sequence":"additional","affiliation":[{"name":"Women\u2019s College Research Institute Women\u2019s College Hospital Toronto ON Canada"},{"name":"ICES Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto Toronto ON Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Chen","sequence":"additional","affiliation":[{"name":"ICES Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0112-7188","authenticated-orcid":false,"given":"Eyal","family":"Cohen","sequence":"additional","affiliation":[{"name":"ICES Toronto ON Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto ON Canada"},{"name":"The Hospital for Sick Children Toronto ON Canada"},{"name":"Department of Paediatrics University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy\u2010Lee","family":"Dennis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto Toronto ON Canada"},{"name":"St Michael\u2019s Hospital Toronto ON Canada"},{"name":"Lawrence S Bloomberg Faculty of Nursing University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel G.","family":"Ray","sequence":"additional","affiliation":[{"name":"ICES Toronto ON Canada"},{"name":"Institute of Health Policy, Management and Evaluation University of Toronto Toronto ON Canada"},{"name":"The Hospital for Sick Children Toronto ON Canada"},{"name":"St Michael\u2019s Hospital Toronto ON Canada"},{"name":"Department of Medicine University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-9639","authenticated-orcid":false,"given":"Simone N.","family":"Vigod","sequence":"additional","affiliation":[{"name":"Women\u2019s College Research Institute Women\u2019s College Hospital Toronto ON Canada"},{"name":"ICES Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"issue":"9","key":"e_1_2_9_2_1","first-page":"1921","article-title":"The global challenge of child injury prevention","volume":"15","author":"Sleet D","year":"2018","journal-title":"Multidisciplinary Digital Publishing Institute"},{"key":"e_1_2_9_3_1","volume-title":"Global Health Estimates 2016: Deaths by Cause, Age, Sex, by Country and by Region, 2000\u20102016","author":"WHO","year":"2018"},{"key":"e_1_2_9_4_1","volume-title":"World report on child injury prevention","author":"Peden M","year":"2009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31467-2"},{"key":"e_1_2_9_6_1","volume-title":"World Report on Child Injury Prevention","author":"Branche C","year":"2008"},{"key":"e_1_2_9_7_1","volume-title":"Injuries in Children Aged 0\u201314 Years and Inequalities","author":"Towner E","year":"2005"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"Cd006020","article-title":"Parenting interventions for the prevention of unintentional injuries in childhood","author":"Kendrick D","year":"2013","journal-title":"Cochrane Database Systematic Rev"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915784"},{"key":"e_1_2_9_10_1","first-page":"1","article-title":"Intervention to prevent child custody loss in mothers with schizophrenia","volume":"2012","author":"Seeman MV","year":"2011","journal-title":"Schizophrenia Res Treat"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.08.034"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30103-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbz001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.1415"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2003.11.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340410790979734"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsn046"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-313809"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.182.1.63"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30069-0"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m853"},{"key":"e_1_2_9_22_1","volume-title":"Care of Women During Pregnancy and Childbirth. Primary Care in Ontario ICES Atlas","author":"Maaten S","year":"2006"},{"key":"e_1_2_9_23_1","volume-title":"A summary of studies on the quality of health care administrative databases in Canada. Patterns of health care in Ontario: the ICES practice atlas","author":"Williams J","year":"1996"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-019-01814-7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.05.010"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2400-x"},{"key":"e_1_2_9_27_1","volume-title":"Reproductive health indicators: guidelines for their generation, interpretation and analysis for global monitoring","author":"World Health Organization","year":"2006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371506000805"},{"key":"e_1_2_9_29_1","volume-title":"Proposed framework for presenting injury data using ICD\u201010\u2010CM external cause of injury codes","author":"Annest JL","year":"2014"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/ip.2005.009076"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/ip.7.4.334"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2335"},{"issue":"2","key":"e_1_2_9_33_1","first-page":"35","article-title":"Identifying deliberate self\u2010harm in emergency department data","volume":"20","author":"Bethell J","year":"2009","journal-title":"Health Rep"},{"key":"e_1_2_9_34_1","volume-title":"The Johns Hopkins ACG System","author":"Johns Hopkins University","year":"2012"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/69.1.239"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1989.10478874"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2307\/1966825"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017719"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15040616"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2019.104172"},{"key":"e_1_2_9_41_1","first-page":"93","volume-title":"Violence against children in the home and family","author":"Pinheiro PS","year":"2006"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-018-1612-0"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796017000397"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712001365"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/19325037.2003.10603586"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60322-5"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796018000847"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715001671"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acps.13281","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T13:40:47Z","timestamp":1693402847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.13281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,11]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/acps.13281"],"URL":"https:\/\/doi.org\/10.1111\/acps.13281","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ACPS.13281\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13281\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13281\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13281\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13281\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13281\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13281\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13281\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13281\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13281\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13281\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13281\/v2\/review1","asserted-by":"object"}]},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,11]]},"assertion":[{"value":"2020-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}