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We aimed to test the association between social support and prognosis independent of treatment type, and the severity of depression, and other clinical features indicating a more severe illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Individual patient data were collated from all six eligible RCTs (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\u00a02858) of adults seeking treatment for depression in primary care. Participants were randomized to any treatment and completed the same baseline assessment of social support and clinical severity factors. Two\u2010stage random effects meta\u2010analyses were conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Social support was associated with prognosis independent of randomized treatment but effects were smaller when adjusting for depressive symptoms and durations of depression and anxiety, history of antidepressant treatment, and comorbid panic disorder: percentage decrease in depressive symptoms at 3\u20134\u00a0months per z\u2010score increase in social support\u00a0=\u00a0\u22124.14(95%CI: \u22126.91 to \u22121.29). Those with a severe lack of social support had considerably worse prognoses than those with no lack of social support: increase in depressive symptoms at 3\u20134\u00a0months\u00a0=\u00a014.64%(4.25% to 26.06%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, large differences in social support pre\u2010treatment were associated with differences in prognostic outcomes. Adding the Social Support scale to clinical assessments may be informative, but after adjusting for routinely assessed clinical prognostic factors the differences in prognosis are unlikely to be of a clinically important magnitude. Future studies might investigate more intensive treatments and more regular clinical reviews to mitigate risks of poor prognosis for those reporting a severe lack of social support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13285","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T14:01:55Z","timestamp":1612792915000},"page":"392-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Is social support pre\u2010treatment associated with prognosis for adults with depression in primary care?"],"prefix":"10.1111","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-0907","authenticated-orcid":false,"given":"Joshua E. 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