{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:17:59Z","timestamp":1787163479948,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","award":["HPF\/2010\/17"],"award-info":[{"award-number":["HPF\/2010\/17"]}],"id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","award":["TRA\/2007\/5"],"award-info":[{"award-number":["TRA\/2007\/5"]}],"id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","award":["TRA\/2007\/5\/R"],"award-info":[{"award-number":["TRA\/2007\/5\/R"]}],"id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Electroconvulsive therapy (ECT) is a rapidly effective treatment for severe depression. Treatment with right unilateral (RUL) or bitemporal (BT) ECT may explain individual differences in speed of ECT effectiveness. There is limited evidence for demographic and clinical factors that predict speed of response and remission with ECT. We aimed to investigate differences in speed of improvement as well as achieving response and remission between twice\u2010weekly brief\u2010pulse high\u2010dose (6 \u00d7 seizure threshold) RUL ECT and moderate\u2010dose (1.5 \u00d7 seizure threshold) BT ECT. We also explored demographic and clinical characteristics that predict speed of response and remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Weekly 24\u2010item Hamilton Depression Rating Scale scores were assessed among patients with severe depression who participated in the EFFECT\u2010Dep trial (ISRCTN23577151). Speed of improvement in patients randomised to RUL ECT (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a069) or BT ECT (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a069) was compared using independent sample t tests. Pearson's chi\u2010square and Fisher's exact tests compared proportions of responders and remitters at each weekly assessment. Predictors of speed of response and remission were explored using Cox regression analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no significant differences between RUL and BT ECT in speed of improvement, response or remission. Exploratory analyses indicated that speed of response and remission were not predicted by a wide variety of demographic and clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ECT electrode placement did not have predictive value when determining speed of improvement, response and remission with ECT. Other clinical factors, such as cognitive side\u2010effects, may be more relevant when making the clinical choice between RUL and BT ECT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13286","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T03:10:49Z","timestamp":1613358649000},"page":"444-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Speed of electroconvulsive therapy for depression: Effects of electrode placement"],"prefix":"10.1111","volume":"143","author":[{"given":"Celine A.","family":"Fox","sequence":"first","affiliation":[{"name":"Department of Psychiatry Trinity College Dublin St. Patrick's University Hospital Dublin 8 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-2799","authenticated-orcid":false,"given":"Declan M.","family":"McLoughlin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Trinity College Dublin St. Patrick's University Hospital Dublin 8 Ireland"},{"name":"Trinity College Institute of Neuroscience Trinity College Dublin Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12705-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716002737"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0406"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.148213"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCT.0000000000000506"},{"issue":"4","key":"e_1_2_10_7_1","first-page":"208","article-title":"Quantifying the speed of symptomatic improvement with electroconvulsive therapy: comparison of alternative statistical methods","volume":"13","author":"Nobler MS","year":"1997","journal-title":"Convuls Ther"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2017.28"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2001.030208.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.05.072"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14r09145"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712000806"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.109.066183"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.37"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12050648"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00124509-200409000-00006"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00124509-199909000-00004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00702.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.02.048"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.10.047"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2012.04.036"},{"issue":"13","key":"e_1_2_10_22_1","first-page":"18","article-title":"Evaluating antidepressant therapies: remission as the optimal outcome","volume":"64","author":"Thase ME","year":"2003","journal-title":"J Clin Psychiatry"},{"issue":"3","key":"e_1_2_10_23_1","first-page":"10s","article-title":"The human cost of not achieving full remission in depression","volume":"49","author":"McIntyre RS","year":"2004","journal-title":"Can J Psychiatry"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCT.0000000000000176"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00124509-200112000-00003"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15030372"},{"key":"e_1_2_10_27_1","volume-title":"Structured Clinical Interview for DSM\u2010 IV Axis I Disorders, Clinician Version (SCID\u2010CV)","author":"First MSR","year":"1996"},{"key":"e_1_2_10_28_1","first-page":"992","volume-title":"Handbook of Depression\u2010Treatment, Assessment and Research","author":"Snaith P","year":"1985"},{"key":"e_1_2_10_29_1","first-page":"28","volume-title":"The ECT Handbook","author":"Dunne R","year":"2013"},{"issue":"16","key":"e_1_2_10_30_1","first-page":"10","article-title":"The definition and meaning of treatment\u2010resistant depression","volume":"62","author":"Sackeim HA","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2017.70.2.144"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"},{"issue":"1","key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","journal-title":"J Roy Stat Soc: Ser B (Methodol)"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.11.024"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acps.13286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T02:50:41Z","timestamp":1724467841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.13286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/acps.13286"],"URL":"https:\/\/doi.org\/10.1111\/acps.13286","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ACPS.13286\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13286\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13286\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13286\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13286\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13286\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13286\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13286\/v1\/review2","asserted-by":"object"}]},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,18]]},"assertion":[{"value":"2020-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}