{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:39:53Z","timestamp":1790372393841,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R268\u20102016\u20103925"],"award-info":[{"award-number":["R268\u20102016\u20103925"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate vagotomy, the severance of the vagus nerve, and its association with mental disorders, as gut\u2010brain communication partly mediated by the vagus nerve have been suggested as a risk factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nationwide population\u2010based Danish register study of all individuals alive and living in Denmark during the study period 1977\u20132016 and who had a hospital contact for ulcer with or without vagotomy. Follow\u2010up was until any diagnosis of mental disorders requiring hospital contact, emigration, death, or end of follow\u2010up on December 31, 2016, whichever came first. Data were analyzed using survival analysis and adjusted for sex, age, calendar year, ulcer type, and Charlson comorbidity index score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, 113,086 individuals had a hospital contact for ulcer. Of these, 5,408 were exposed to vagotomy where 375 (6.9%) subsequently developed a mental disorder. Vagotomy overall was not associated with mental disorders (HR: 1.10; 95%CI: 0.99\u20131.23), compared to individuals with ulcer not exposed to vagotomy. However, truncal vagotomy was associated with an increased HR of 1.22 (95%CI: 1.06\u20131.41) for mental disorders, whereas highly selective vagotomy was not associated with mental disorders (HR: 0.98; 95%CI: 0.84\u20131.15). Truncal vagotomy was also associated with higher risk of mental disorders when compared to highly selective vagotomy (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, vagotomy did not increase the risk of mental disorders; however, truncal vagotomy specifically was associated with a small risk increase in mental disorders, whereas no association was found for highly selective vagotomy. Thus, the vagus nerve does not seem to have a major impact on the development of mental disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13343","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T16:23:00Z","timestamp":1625156580000},"page":"67-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Vagotomy and the risk of mental disorders: A nationwide population\u2010based study"],"prefix":"10.1111","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-4022","authenticated-orcid":false,"given":"Artemis H.","family":"Bunyoz","sequence":"first","affiliation":[{"name":"Copenhagen Research Center for Mental Health \u2013 CORE Mental Health Centre Copenhagen Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune H. 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B.","family":"Mortensen","sequence":"additional","affiliation":[{"name":"iPSYCH The Lundbeck Foundation Initiative for Integrative Psychiatric Research Lundbeck Denmark"},{"name":"National Centre for Register\u2010based Research Department of Economics and Business Economics Aarhus University Aarhus Denmark"},{"name":"Department of Economics CIRRAU \u2013 Centre for Integrated Register\u2010based Research Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liselotte V.","family":"Petersen","sequence":"additional","affiliation":[{"name":"iPSYCH The Lundbeck Foundation Initiative for Integrative Psychiatric Research Lundbeck Denmark"},{"name":"National Centre for Register\u2010based Research Department of Economics and Business Economics Aarhus University Aarhus Denmark"},{"name":"Department of Economics CIRRAU \u2013 Centre for Integrated Register\u2010based Research Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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