{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:03:16Z","timestamp":1785466996163,"version":"3.56.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the 10\u2010year stability of schizophrenia diagnosis in a cohort of first\u2010episode psychosis (FEP) patients and the factors associated with it.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Changes in diagnosis of 209 FEP patients were described during 10\u00a0years of follow\u2010up. Related factors with maintenance or change of schizophrenia diagnosis were evaluated in prospective and retrospective approaches through binary logistic regressions, ROC and survival curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of the 209 patients, 126 were diagnosed of schizophrenia 6\u00a0months after their inclusion in the clinical program. Prospective analyses showed that eight of those 126\u00a0schizophrenia patients had changed to a different diagnosis after 10\u00a0years, and predictors of change were better childhood premorbid adjustment, less severity of clinical global impression at baseline, and diagnosis of comorbid personality disorder during follow\u2010up. Retrospectively, out of the 154 patients with schizophrenia in the 10\u2010year assessment, 36\u00a0had a different diagnosis at baseline, and those factors related to a different prior diagnosis than schizophrenia were better socioeconomic status and shorter duration of untreated psychosis (DUP). A survival analysis on the timing of schizophrenia diagnosis showed that male gender and longer DUP were predictors of earlier definite diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diagnostic stability of schizophrenia in our FEP sample is high, especially prospective stability, and the group of patients with diagnostic change corresponded to a milder psychopathological profile before and at the onset of disease. Moreover, we observed a cautious attitude in the diagnosis of schizophrenia in patients with shorter DUP who had schizophrenia diagnosis after 10\u00a0years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13344","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T13:16:00Z","timestamp":1625577360000},"page":"342-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stability of schizophrenia diagnosis in a 10\u2010year longitudinal study on first episode of non\u2010affective psychosis: Conclusions from the PAFIP cohort"],"prefix":"10.1111","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-1718","authenticated-orcid":false,"given":"Paula","family":"Su\u00e1rez\u2010Pinilla","sequence":"first","affiliation":[{"name":"Department of Psychiatry University Hospital Marqu\u00e9s de Valdecilla IDIVAL Santander Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6437-3741","authenticated-orcid":false,"given":"Marta","family":"Su\u00e1rez\u2010Pinilla","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease Institute of Neurology University College of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8027-6546","authenticated-orcid":false,"given":"Esther","family":"Seti\u00e9n\u2010Suero","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospital Marqu\u00e9s de Valdecilla IDIVAL Santander Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Ortiz\u2010Garc\u00eda de la Foz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospital Marqu\u00e9s de Valdecilla IDIVAL Santander Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Mayoral\u2010Van Son","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) Instituto de Salud Carlos III Madrid Spain"},{"name":"Department of Psychiatry School of Medicine University Hospital Virgen del Roc\u00edo \u2010 IBiS Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5478-3376","authenticated-orcid":false,"given":"Javier","family":"V\u00e1zquez\u2010Bourgon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospital Marqu\u00e9s de Valdecilla IDIVAL Santander Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"G\u00f3mez\u2010Revuelta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospital Marqu\u00e9s de Valdecilla IDIVAL Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Juncal\u2010Ru\u00edz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry IDIVAL School of Medicine Sierrallana Hospital University of Cantabria Torrelavega Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Ayesa\u2010Arriola","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospital Marqu\u00e9s de Valdecilla IDIVAL Santander Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicto","family":"Crespo\u2010Facorro","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM) Instituto de Salud Carlos III Madrid Spain"},{"name":"Department of Psychiatry School of Medicine University Hospital Virgen del Roc\u00edo \u2010 IBiS Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn117"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212802884609"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(02)00014-X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00084"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S120298"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.01.024"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000284"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.109.074526"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n1006"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"Schizophrenia","volume":"1","author":"Kahn RS","year":"2015","journal-title":"Nat Rev Dis Prim"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.07.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2019.07.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.170.4.321"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmh.8.3.68"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.185.6.460"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.04.018"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000146070"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.6.593"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00048670701332276"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.175.6.537"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715000720"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbi030"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638237.2020.1818191"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw020"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2008.00074.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.05.002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719003179"},{"key":"e_1_2_8_31_1","volume-title":"User\u2019s guide for the structured clinical interview for DSM\u2010IV axis I Disorders \u2010 Research version","author":"First MB","year":"1996"},{"key":"e_1_2_8_32_1","series-title":"Personality assessment","first-page":"134","volume-title":"Comprehensive handbook of psychological assessment","author":"First MB","year":"2004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/8.3.470"},{"key":"e_1_2_8_34_1","volume-title":"Scale for the Assessment of Negative Symptoms (SANS)","author":"Andreassen N","year":"1983"},{"key":"e_1_2_8_35_1","volume-title":"Scale for the Assessment of Positive Symptoms (SAPS)","author":"Andreassen N","year":"1983"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1973.33.3.783"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000292581"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_8_39_1","first-page":"218","volume-title":"ECDEU Assessment Manual for Psychopharmacology\u2010Revised","author":"Guy W","year":"1976"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.3.441"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.05.001"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09540"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-016-0740-3"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.03.025"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.02.014"},{"key":"e_1_2_8_47_1","doi-asserted-by":"crossref","unstructured":"ArciniegasDB.Psychosis. Contin. Lifelong Learn. Neurol.2015;21:715\u2010736.","DOI":"10.1212\/01.CON.0000466662.89908.e7"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.102"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw132"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2014.07.002"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn135"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09563"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(14)00023-6"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.9.975"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.10.003"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a006850"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.9.1453"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acps.13344","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:26:57Z","timestamp":1693344417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.13344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,21]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/acps.13344"],"URL":"https:\/\/doi.org\/10.1111\/acps.13344","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ACPS.13344\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13344\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13344\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13344\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13344\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,21]]},"assertion":[{"value":"2021-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}