{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:28:06Z","timestamp":1784042886807,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Meta\u2010analyses have established a heightened risk of suicidality for youth treated with selective serotonin reuptake inhibitors (SSRIs). The present study investigates the risk and possible predictors of suicidality and non\u2010suicidal self\u2010injury (NSSI) associated with SSRI treatment in a clinical sample of children and adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational, longitudinal, retrospective study using a within\u2010subject study design including in\u2010 and outpatients aged 0\u201317\u00a0years treated with SSRIs. Data were obtained from digital medical records and prescription software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0365 patients were included (64.1% female), mean (SD) age 14.5 (2.04) years, with primary depression, anxiety or obsessive\u2010compulsive disorder. No suicides occurred. When comparing the 6\u2010week period immediately prior to versus following SSRI initiation, the patient proportion with broadly defined suicidality decreased (38.5% vs. 24.2%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001) while the proportion with suicide attempts was stable (2.8% vs. 2.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a01.000). The proportion with NSSI decreased statistically non\u2010significantly (12.4% vs. 8.4%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.067). Results from individually standardized observation periods were similar; however, the proportion with suicide attempts decreased statistically non\u2010significantly and the proportion with NSSI decreased significantly. Suicidality during SSRI treatment was associated with previous suicidality (OR[CI]\u00a0=\u00a06.0 [2.4\u201314.8],\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001), depression as indication for SSRI treatment (OR[CI]\u00a0=\u00a02.1 [1.2\u20133.7],\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.01), female sex (OR[CI]\u00a0=\u00a02.1 [1.1\u20134.1],\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.02) and previous NSSI (OR[CI]\u00a0=\u00a02.0 [1.2\u20133.5],\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Suicidality was common in youth treated with SSRIs. The patient proportion with overall suicidality decreased, and the proportion with attempted suicide was stable in the weeks following SSRI initiation. Previous suicidality, depression, female sex and previous NSSI are important predictors for suicidality during SSRI treatment in youth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13360","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T21:06:53Z","timestamp":1628543213000},"page":"209-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Suicidality and self\u2010injury with selective serotonin reuptake inhibitors in youth: Occurrence, predictors and timing"],"prefix":"10.1111","volume":"145","author":[{"given":"Johanne \u00d8sterby","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Child and Adolescent Mental Health Center Mental Health Services Capital Region of Denmark Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Mental Health Services Capital Region of Denmark Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels","family":"Roesbjerg","sequence":"additional","affiliation":[{"name":"Mental Health Services Capital Region of Denmark Copenhagen \u00d8 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank C.","family":"Verhulst","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Mental Health Services Capital Region of Denmark Hellerup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Katrine","family":"Pagsberg","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Mental Health Services Capital Region of Denmark Hellerup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.02.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i65"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12655"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.15.1683"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.3.332"},{"key":"e_1_2_9_7_1","first-page":"CD004851","article-title":"Newer generation antidepressants for depressive disorders in children and adolescents","volume":"11","author":"Hetrick SE","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2006.16.91"},{"key":"e_1_2_9_9_1","unstructured":"FDASuicidality in Children and Adolescents Being Treated With Antidepressant Medications;https:\/\/www.fda.gov\/drugs\/postmarket\u2010drug\u2010safety\u2010information\u2010patients\u2010and\u2010providers\/suicidality\u2010children\u2010and\u2010adolescents\u2010being\u2010treated\u2010antidepressant\u2010medications. 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