{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:24:47Z","timestamp":1790515487588,"version":"4.1.0"},"reference-count":107,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Although a relationship between schizophrenia (SCZ), antipsychotic (AP) medication, and metabolic dysregulation is now well established, the effect of adiposity is less well understood. By synthesizing findings from imaging techniques that measure adiposity, our systematic review and meta\u2010analysis (PROSPERO CRD42020192977) aims to determine the adiposity\u2010related effects of illness and treatment in this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched MEDLINE, EMBASE, PsychINFO and Scopus for all relevant case\u2010control and prospective longitudinal studies from inception until February 2021. Measures of adiposity including percent body fat (%BF), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) were analyzed as primary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our search identified 29 articles that used imaging methods to quantify adiposity among patients with SCZ spectrum disorders. Analyses revealed that patients have greater %BF (mean difference (MD)\u00a0=\u00a03.09%; 95% CI: 0.75\u20135.44), SAT (MD\u00a0=\u00a024.29\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      ; 95% CI: 2.97\u201345.61) and VAT (MD\u00a0=\u00a033.73\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      , 95% CI: 4.19\u201363.27) compared to healthy controls. AP treatment was found to increase SAT (MD\u00a0=\u00a031.98\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      ; 95% CI: 11.33\u201352.64) and VAT (MD\u00a0=\u00a016.30\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      ; 95% CI: 8.17\u201324.44) with no effect on %BF. However, change in %BF was higher for AP\u2010free\/AP\u2010na\u00efve patients compared to treated patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that patients with SCZ spectrum disorders have greater adiposity than healthy controls, which is increased by AP treatment. Young, AP\u2010na\u00efve patients may be particularly susceptible to this effect. Future studies should explore the effect of specific APs on adiposity and its relation to overall metabolic health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13365","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T04:25:49Z","timestamp":1630297549000},"page":"524-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Adiposity in schizophrenia: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"144","author":[{"given":"Emily","family":"Smith","sequence":"first","affiliation":[{"name":"Schizophrenia Division Centre for Addiction and Mental Health (CAMH) Toronto Ontario Canada"},{"name":"Institute of Medical Science Temerty Faculty of Medicine University of Toronto Toronto Ontario 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