{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:53:10Z","timestamp":1793764390439,"version":"4.6.1"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>A substantial proportion of patients with schizophrenia suffer from comorbid obsessive\u2010compulsive disorder (OCD) possibly associated with antipsychotics. However, little is known about the comparative risks of the antipsychotics. The present study aimed to investigate the risk of new\u2010onset OCD following the initiation of different antipsychotic medications for schizophrenia relative to haloperidol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Korean national claims data, patients aged 15\u201360\u00a0years newly diagnosed with schizophrenia between 2010 and 2018 were identified. Of the 47,808 patients with schizophrenia treated with nine commonly prescribed antipsychotics, 775 new\u2010onset OCD patients were matched to 3,100 patients without OCD using nested case\u2010control design with 1:4 case\u2010control matching based on the sex, age of index date, date of schizophrenia diagnosis, observation period, locations of medical institutions, and level of medical facilities. Using multivariable conditional logistic regression analysis, odd ratios (ORs) for new\u2010onset OCD comparing each antipsychotic agent relative to haloperidol were computed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risk for new\u2010onset OCD during treatment with clozapine was significantly higher than that with haloperidol (adjusted OR 2.86; 95% confidence interval [1.63\u20135.03]). The risks for new\u2010onset OCD with other antipsychotics were not significantly different from that with haloperidol.\u00a0In subgroup analysis, the early and intermediate, but not late\u2010onset schizophrenia group showed significant risk for OCD associated with clozapine use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present findings, based on real\u2010world national representative data, provide reliable evidence for the risk of new\u2010onset OCD in patients with schizophrenia receiving clozapine at a population level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13375","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T12:46:47Z","timestamp":1632660407000},"page":"589-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A nationwide nested case\u2010control study of new\u2010onset obsessive\u2010compulsive disorder following 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