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To aid treatment decision\u2010making for clinicians, patients and their carers, we conducted a systematic review and meta\u2010analysis to identify potential risk factors for clozapine\u2010induced myocarditis and cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted of PubMed, Embase, CINAHL, Web of Science, Cochrane and PsycInfo for studies reporting myocarditis and cardiomyopathy among people on clozapine and potential risk factors. We calculated pooled effect sizes on risk factors using a random\u2010effects meta\u2010analytic model. Risk of publication bias was assessed using the Newcastle\u2010Ottawa scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven studies met the inclusion criteria, of which six studies had quantitative data included in the meta\u2010analysis. The odds of clozapine\u2010induced myocarditis increased with concurrent sodium valproate use (\n                      <jats:italic>k<\/jats:italic>\n                      \u00a0=\u00a06,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0903, pooled OR 3.58, 95% CI 1.81\u20137.06), but were not significantly greater with the use of quetiapine, lithium or selective serotonin reuptake inhibitors. Our qualitative review identified conflicting results reported for increasing age and higher clozapine dose as risk factors for myocarditis. No other factors, including genetic risk, sex, ethnicity, smoking, alcohol, substance abuse or cardiometabolic disease, were associated with greater odds of myocarditis. No risk factors for cardiomyopathy were identified in the literature.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Concurrent use of sodium valproate increases the odds of clozapine\u2010induced myocarditis. Thus, clinicians should consider the temporary cessation of sodium valproate during the initial titration phase of clozapine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13398","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T23:58:50Z","timestamp":1642982330000},"page":"442-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Risk factors for clozapine\u2010induced myocarditis and cardiomyopathy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"145","author":[{"given":"Mark","family":"Vickers","sequence":"first","affiliation":[{"name":"Metro North Mental Health Service Royal Brisbane and Women\u2019s Hospital Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland Brisbane Queensland Australia"},{"name":"Faculty of Health Queensland University of Technology Brisbane Queensland 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