{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:40:53Z","timestamp":1790685653629,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006751","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Polypharmacy and overprescription of off\u2010label medications are common in patients with borderline personality disorder (BPD). The aim of the present naturalistic study was to explore whether the skills training module of dialectical\u2010behavioural therapy (DBT) can reduce polypharmacy in these patients in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective, observational study of 377 patients with a primary diagnosis of BPD consecutively admitted to the BPD outpatient unit from 2010 through 2020. All patients were invited to participate in the DBT skills training module (DBT\u2010ST). DBT\u2010ST participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0182) were compared with a control group who did not participate in DBT\u2010ST (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0195). Pre\u2010post intervention changes in medication load and use of antidepressants, benzodiazepines, mood stabilizers, and antipsychotics were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, most patients (84.4%) were taking at least one medication and 46.9% were on polypharmacy. Compared to controls, patients in the DBT\u2010ST group presented a significant reduction in the number of medications (2.67\u20131.95 vs. 2.16\u20132.19;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), medication load (4.25\u20133.05 vs. 3.45\u20133.48;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), use of benzodiazepines (54.4%\u201327.5% vs. 40%\u201340.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), mood stabilizers (43.4%\u201333% vs. 36.4%\u201339.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and antipsychotics (36.3%\u201329.1% vs. 34.4%\u201336.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that patients with BPD can benefit from the DBT\u2010ST module, which may reduce the medication load, particularly of sedatives. The results suggest that DBT\u2010ST may be useful to treat overmedication in patients with BPD and could help to promote \u201cdeprescription\u201d in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13403","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T20:19:00Z","timestamp":1643314740000},"page":"332-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["\u201cSkills for pills\u201d: The dialectical\u2010behavioural therapy skills training reduces polypharmacy in borderline personality disorder"],"prefix":"10.1111","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8077-3641","authenticated-orcid":false,"given":"Joaquim","family":"Soler","sequence":"first","affiliation":[{"name":"Department of Psychiatry Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB) Barcelona Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica\u2010 Sant Pau (IIB\u2010SANT PAU) Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8496-0719","authenticated-orcid":false,"given":"Elisabet","family":"Casellas\u2010Pujol","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB) Barcelona Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica\u2010 Sant Pau (IIB\u2010SANT PAU) Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Fern\u00e1ndez\u2010Felipe","sequence":"additional","affiliation":[{"name":"Labpsitec Laboratorio de Psicolog\u00eda y Tecnolog\u00eda. 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Psicolog\u00eda B\u00e1sica Cl\u00ednica y Psicobiolog\u00eda Universitat Jaume I Castell\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-0854","authenticated-orcid":false,"given":"Ana","family":"Mart\u00edn\u2010Blanco","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB) Barcelona Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica\u2010 Sant Pau (IIB\u2010SANT PAU) Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Almenta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB) Barcelona Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica\u2010 Sant Pau (IIB\u2010SANT PAU) Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8039-9346","authenticated-orcid":false,"given":"Juan C.","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB) Barcelona Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica\u2010 Sant Pau (IIB\u2010SANT PAU) Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0404"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1521\/pedi.2010.24.4.412"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1521\/pedi_2016_30_269"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13651501.2019.1576904"},{"issue":"8","key":"e_1_2_10_7_1","first-page":"CD005652","article-title":"Psychological therapies for people with borderline personality disorder","author":"Stoffers\u2010Winterling JM","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"e_1_2_10_8_1","first-page":"1","article-title":"European guidelines for personality disorders: past, present and future","volume":"6","author":"Simonsen S","year":"2019","journal-title":"Borderline Pers Disord Emot Dysregulation"},{"key":"e_1_2_10_9_1","unstructured":"National Institute for Health and Clinical Excellence. 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