{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:19Z","timestamp":1772159959102,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Many psychiatric diseases have a strong familial aggregation, but it is unknown whether postpartum depression (PPD) without prior psychiatric history aggregates in families.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Based on Danish national registers, we constructed a cohort with information on 848,544 singleton deliveries (1996\u20132017). Women with an episode of PPD were defined as having used antidepressant medication and\/or had a hospital contact for depression within 6\u00a0months after delivery. Those with psychiatric history prior to the delivery were excluded. We estimated relative risk (RR) of PPD, comparing women with female relatives with and without PPD history, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, women with a PPD history in female blood relatives had themselves a higher risk of PPD (RR\u00a0=\u00a01.64, 95% CI 1.16\u20132.34). Having the first\u2010degree female relative with PPD history was associated with a more than 2.5 times (RR\u00a0=\u00a02.65, 95% CI 1.79\u20133.91) increased risk of PPD. However, having the second\/third\u2010degree female relative and\/or a female non\u2010blood relative with PPD history did not increase the woman's own risk of PPD (RR\u00a0=\u00a00.58, 95% CI 0.26\u20131.28, RR\u00a0=\u00a01.09, 95% CI 0.83\u20131.44).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Postpartum depression aggregates in families with no other psychiatric history, but the findings do not support a strong genetic trait as a major cause. Other possible mechanisms are shared environment and\/or health\u2010seeking behavior in close relationships.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13465","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T10:05:44Z","timestamp":1655892344000},"page":"340-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Familial risk of postpartum depression"],"prefix":"10.1111","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-593X","authenticated-orcid":false,"given":"Marie\u2010Louise H.","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gry J.","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Wohlfahrt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poul","family":"Videbech","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Depression Research Mental Health Center  Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads","family":"Melbye","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Fertility and Health Norwegian Institute of Public Health  Oslo Norway"},{"name":"K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Faculty of Medicine Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Genetics Stanford University School of Medicine  Stanford California 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