{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:30:28Z","timestamp":1781796628996,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Delirium is common and serious complication after stroke. Accurate prediction of delirium is important for prevention and monitoring of high\u2010risk patients. Our study aimed to determine if addition of C\u2010reactive protein (CRP) to a model based on easy\u2010to\u2010access clinical predictors improves accuracy of delirium prediction in acute stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data of patients participating in the Prospective Observational Polish Study on post\u2010stroke delirium. We included patients admitted within 24\u2009h after stroke or transient ischemic attack (TIA) in whom serum CRP was measured on admission. We examined core features of delirium during first 7\u2009days of hospitalization. We assessed if addition of CRP to two clinical models improved metrics of discrimination and reclassification. Model A included age and stroke severity and Model B included stroke severity, atrial fibrillation, diabetes mellitus, pre\u2010stroke dependency, and hemorrhagic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 459 patients. We diagnosed delirium in 29.2% of them. Patients who developed delirium had higher CRP level than those without delirium (median: 13.2 vs. 4.4\u00a0mg\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). CRP &gt;7.09\u2009mg\/L was associated with an increased risk of delirium (adjusted OR: 2.98, 95%CI: 1.71\u20135.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After adding CRP to clinical models, an area under receiver operator curve increased from 0.77 to 0.80 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.038) for Model A and from 0.81 to 0.84 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.016) for Model B. There was also improvement in reclassification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Addition of CRP to clinical predictors moderately improved prediction of post\u2010stroke delirium. CRP could be considered as a potential biomarker to stratify risk of delirium after stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13489","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T04:39:15Z","timestamp":1661229555000},"page":"536-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Serum\n                    <scp>C<\/scp>\n                    \u2010reactive protein adds predictive information for post\u2010stroke delirium: The\n                    <scp>PROPOLIS<\/scp>\n                    study"],"prefix":"10.1111","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1219-0062","authenticated-orcid":false,"given":"Elzbieta","family":"Klimiec\u2010Moskal","sequence":"first","affiliation":[{"name":"Department of Neurology Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Slowik","sequence":"additional","affiliation":[{"name":"Department of Neurology Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Dziedzic","sequence":"additional","affiliation":[{"name":"Department of Neurology Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60688-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00223-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2273"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0548-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2021.110530"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.07.012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.01.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2013.09.002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13441"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14913"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025015"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318210411f"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-021-02071-y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15144"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211059636"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987321997045"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-015-0351-z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2013.05.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.21.2703"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610213002585"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.7.864"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.604"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.152.2.209"},{"issue":"11","key":"e_1_2_9_26_1","article-title":"Informant questionnaire on cognitive decline in the elderly (IQCODE) for the early diagnosis of dementia across a variety of healthcare settings","volume":"11","author":"Harrison JK","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-304920"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2929"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013121300"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41512-018-0037-2"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182887944"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afl121"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afp038"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8071075"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab133"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1156-y"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2021.01.065"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.08.006"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acps.13489","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T10:14:00Z","timestamp":1692699240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.13489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/acps.13489"],"URL":"https:\/\/doi.org\/10.1111\/acps.13489","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ACPS.13489\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13489\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13489\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13489\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13489\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13489\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13489\/v2\/review1","asserted-by":"object"}]},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,31]]},"assertion":[{"value":"2022-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}