{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:09:20Z","timestamp":1788973760463,"version":"build-2803163510"},"reference-count":77,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017225","name":"Aretaeus Foundation of Rome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Research findings on factors associated with onset\u2010age (OA) with bipolar (BD) and major depressive disorders (MDD) have been inconsistent, but often indicate greater morbidity following early OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We considered factors associated with OA in 1033 carefully evaluated, systematically followed mood disorder subjects with DSM\u20105 BD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0505) or MDD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0528), comparing rates of descriptive and clinical characteristics following early (age\u2009&lt;18), intermediate (18\u201340), or later onset (\u226540\u2009years), as well as regressing selected measures versus OA. Exposure time (years ill) was matched among these subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As hypothesized, many features were associated with early OA: familial psychiatric illness, including BD, greater maternal age, early sexual abuse, nondepressive first episodes, co\u2010occurring ADHD, suicide attempts and violent suicidal behavior, abuse of alcohol or drugs, smoking, and unemployment. Other features increased consistently with later OA: %\u2010time\u2010depressed (in BD and MDD, women and men), as well as depressions\/year and intake ratings of depression, educational levels, co\u2010occurring medical disorders, rates of marriage and number of children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OA averaged 7.5\u2009years earlier in BD versus MDD (30.7 vs. 38.2). Some OA\u2010associated measures may reflect maturation. Associations with family history and suicidal risk with earlier OA were expected; increases of time\u2010depressed in both BD and MDD with later OA were not. We conclude that associations of OA with later morbidity are complex and not unidirectional but may be clinically useful.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13497","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T02:00:18Z","timestamp":1662343218000},"page":"456-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Factors associated with onset\u2010age in major affective disorders"],"prefix":"10.1111","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2513-2718","authenticated-orcid":false,"given":"Alessandro","family":"Miola","sequence":"first","affiliation":[{"name":"International Consortium for Mood &amp; Psychotic Disorders Research, Mailman Research Center McLean Hospital  Belmont Massachusetts USA"},{"name":"Department of Psychiatry University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Tondo","sequence":"additional","affiliation":[{"name":"International Consortium for Mood &amp; Psychotic Disorders Research, Mailman Research Center McLean Hospital  Belmont Massachusetts USA"},{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"},{"name":"Lucio Bini Mood Disorder Centers  Cagliari Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2561-8352","authenticated-orcid":false,"given":"Paola","family":"Salvatore","sequence":"additional","affiliation":[{"name":"International Consortium for Mood &amp; Psychotic Disorders Research, Mailman Research Center McLean Hospital  Belmont Massachusetts USA"},{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"},{"name":"Center for Healthcare Organization &amp; Implementation Research US Veterans Administration Medical Center  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