{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:13:15Z","timestamp":1776460395200,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["315969"],"award-info":[{"award-number":["315969"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["320107"],"award-info":[{"award-number":["320107"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["345326"],"award-info":[{"award-number":["345326"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Mood stabilizers (MS) are often used as adjunctive medication in patients with schizophrenia. The aim of this study was to investigate the real\u2010world effectiveness of MS use in persons with schizophrenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study cohort included all persons treated in inpatient care due to schizophrenia during 1972\u20132014 in Finland (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u200961,889). Drug purchase data were obtained from the national Prescription register and modeled with the PRE2DUP method. The follow\u2010up period covered the years 1996\u20132017. Mood stabilizers included carbamazepine, valproic acid, lamotrigine, and lithium. The main outcome was psychosis hospitalization. We utilized within\u2010individual design to compare the risk of outcome between time\u2010periods of MS use and non\u2010use within the same person. Stratified Cox regression analyses were conducted with adjusted hazard ratios (aHR) and 95% confidence intervals (CIs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age at cohort entry was 46.2\u2009years (SD 16.0) and 50.3% were male. During the follow\u2010up (maximum of 22\u2009years, median 14.8\u2009years, interquartile range 7.5\u201322.0), 28.1% (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u200917,370) of the study cohort used MS, valproic acid being the most often used one (60.4%,\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u200910,483). Risk of psychosis hospitalization was lower during MS use than non\u2010use (aHR 0.88, 95% CI 0.86\u20130.90). Use of lithium (0.84, 0.81\u20130.87), valproic acid (0.87, 0.85\u20130.90), and lamotrigine (0.90, 0.85\u20130.95) were associated with lower risk of psychosis hospitalization compared with their non\u2010use, whereas carbamazepine use was not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mood stabilizers were relatively often used as adjunctive treatments in schizophrenia and their use was associated with a 12% decreased risk of psychosis rehospitalization, a marker of relapse in schizophrenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13498","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T01:55:40Z","timestamp":1662429340000},"page":"257-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Real\u2010world effectiveness of mood stabilizer use in schizophrenia"],"prefix":"10.1111","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5897-4583","authenticated-orcid":false,"given":"Arto","family":"Puranen","sequence":"first","affiliation":[{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital University of Eastern Finland  Kuopio Finland"},{"name":"School of Pharmacy University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjaana","family":"Koponen","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Eastern Finland  Kuopio Finland"},{"name":"Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences Monash University  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku","family":"L\u00e4hteenvuo","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Tanskanen","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital University of Eastern Finland  Kuopio Finland"},{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jari","family":"Tiihonen","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital University of Eastern Finland  Kuopio Finland"},{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Center for Psychiatry Research Stockholm City Council  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Taipale","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital University of Eastern Finland  Kuopio Finland"},{"name":"School of Pharmacy University of Eastern Finland  Kuopio Finland"},{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Center for Psychiatry Research Stockholm City Council  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Schizophrenia: Current Care Guideline; 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