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Empirical evidence for delirium\u2010associated medication is uncertain due to a lack of high\u2010quality studies. We aimed to further investigate the body of evidence for drugs suspected to trigger delirium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic update review and meta\u2010analyses of prospective studies presenting drug associations with incident delirium in adult study populations was conducted. Two authors independently searched MEDLINE, PsycINFO, Embase, and Google Scholar dated from October 1, 2009 to June 23, 2020, after screening a previous review published in 2011. The most reliable results on drug\u2010delirium associations were pooled in meta\u2010analyses using the random\u2010effects model. Quality of evidence was assessed using the GRADE\u2010approach. This study is preregistered with OSF (DOI\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/doi.org.10.17605\/OSF.IO\/4PUHY\">https:\/\/doi.org.10.17605\/OSF.IO\/4PUHY<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 31 eligible studies, presenting results for 24 medication classes were identified. Meta\u2010analyses and GRADE level of evidence ratings show no increased delirium risk for Haloperidol (OR: 0.96, 95% CI 0.72\u20131.28; high\u2010quality evidence), Olanzapine (OR: 0.25, 95% CI 0.15\u20130.40), Ketamine (OR: 0.72, 95% CI 0.35\u20131.46) or corticosteroids (OR: 0.69, 95% CI 0.32\u20131.50; moderate quality evidence, respectively). Low\u2010level evidence suggests a three\u2010fold increased risk for anticholinergics (OR: 3.11, 95% CI 1.04\u20139.26). Opioids, benzodiazepines, H\n                      <jats:sub>1<\/jats:sub>\n                      \u2010antihistamines, and antidepressants did not reach reliable evidence levels in our analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We investigated the retrievable body of evidence for delirium\u2010associated medication. The results of this systematic review were then interpreted in conjunction with other evidence\u2010based works and guidelines providing conclusions for clinical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13505","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T05:23:10Z","timestamp":1664342590000},"page":"16-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Delirium\u2010associated medication in people at risk: A systematic update review, meta\u2010analyses, and\n                    <scp>GRADE<\/scp>\n                    \u2010profiles"],"prefix":"10.1111","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7779-4791","authenticated-orcid":false,"given":"Michael","family":"Reisinger","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Psychotherapeutic Medicine Medical University of Graz  Graz Austria"},{"name":"Department of Neurology Klinik Donaustadt  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-4087","authenticated-orcid":false,"given":"Eva Z.","family":"Reininghaus","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Psychotherapeutic Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-3603","authenticated-orcid":false,"given":"Johanna De","family":"Biasi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Psychotherapeutic Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-3848","authenticated-orcid":false,"given":"Frederike T.","family":"Fellendorf","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Psychotherapeutic Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-0570","authenticated-orcid":false,"given":"Daniela","family":"Schoberer","sequence":"additional","affiliation":[{"name":"Institute of Nursing Science Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/AGEING\/AFAA040"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)60688\u20101"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMCP1605501"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052321"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/PGMJ.2003.017236"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u201000223\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005594.pub3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/APPI.PSY.46.4.302"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq140"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S5358"},{"key":"e_1_2_11_12_1","volume-title":"Delirium: Prevention, Diagnosis and Management","year":"2019"},{"key":"e_1_2_11_13_1","unstructured":"Higgins JPT Thomas J Chandler J et al. 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