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the relationship between mood and inflammation among patients with bipolar disorder (BD) is still unclear. We aimed to investigate the longitudinal associations of pro\u2010inflammatory markers with mood symptom severity in BD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Hundred and thirty\u2010two adult patients with BD were enrolled. At the baseline and 1\u2010year follow\u2010up visit, all participants received mood assessment with Montgomery \u00c5sberg depression rating scale (MADRS) and Young mania rating scale, and underwent blood draws to quantify metabolic profile and serum levels of the pro\u2010inflammatory markers, including soluble interleukin\u20106 receptor, soluble tumor necrosis factor\u2010\u03b1 receptor type 1 (sTNF\u2010\u03b1R1), monocyte chemoattractant protein\u20101, and C\u2010reactive protein. A four\u2010factor model of MADRS, consisting of sadness, negative thoughts, detachment, and neurovegetative symptoms, were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, 65 patients with BD were in depressed state, and 67 patients with BD were in euthymic state. Among patients in depressed state, baseline MADRS total score positively correlated with sTNF\u2010\u03b1R1 level at follow\u2010up. While baseline sTNF\u2010\u03b1R1 level positively predicted sadness symptom in euthymic patients with BD who later developed depression (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a022), sadness in patients with bipolar depression predicted later increase in serum sTNF\u2010\u03b1R1 level even after remission (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a017). Moreover, lithium had a stronger effect of lowering peripheral sTNF\u2010\u03b1R1 level as compared with other mood stabilizers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results indicate the bidirectional inflammation\u2010depression relationship in BD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13508","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:34:48Z","timestamp":1665448488000},"page":"81-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A longitudinal study of the association between pro\u2010inflammatory cytokines and mood symptoms in bipolar disorder"],"prefix":"10.1111","volume":"147","author":[{"given":"Mao\u2010Hsuan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Psychiatry Taipei Veterans General Hospital, Yuanshan and Suao Branch  Ilan Taiwan"},{"name":"Division of Psychiatry, Faculty of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Institute of Brain Science National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee\u2010Lam E.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry General Cheng Hsin Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-1073","authenticated-orcid":false,"given":"Mu\u2010Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, Faculty of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Psychiatry Taipei Veterans General Hospital  Taipei 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