{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:03Z","timestamp":1787013783735,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008018","name":"Victorian Cancer Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gerontology and ageing research are increasingly focussing on healthy life span (healthspan), the period of life lived free of serious disease and disability. Late\u2010life depression (LLD) is believed to impact adversely on physical health. However, no studies have examined its effect on healthspan. This study investigated the effect of LLD and subthreshold depression on disability\u2010free survival, a widely accepted measure of healthspan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study used data from the ASPirin in Reducing Events in the Elderly study. Participants were aged \u226570\u2009years (or \u226565\u2009years for African\u2010American and Hispanic participants) and free of dementia, physical disability and cardiovascular disease. Depressive symptoms were measured using the 10\u2010item Centre for Epidemiological Studies Depression Scale (CES\u2010D\u201010). LLD and subthreshold depression were defined as CES\u2010D\u201010 scores \u22658 and 3\u20137, respectively. Disability\u2010free survival was defined as survival free of dementia and persistent physical disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 19,110 participants were followed up for a maximum of 7.3\u2009years. In female participants, LLD was associated with lower disability\u2010free survival adjusting for sociodemographic and lifestyle factors, medical comorbidities, polypharmacy, physical function and antidepressant use (HR, 1.50; 95% CI, 1.23\u20131.82). In male participants, LLD was associated with lower disability\u2010free survival adjusting for sociodemographic and lifestyle factors (HR, 1.30; 95% CI, 1.03\u20131.64). Subthreshold depression was also associated with lower disability\u2010free survival in both sexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LLD may be a common and important risk factor for shortened healthspan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13513","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T07:43:14Z","timestamp":1666683794000},"page":"92-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The effect of depressive symptoms on disability\u2010free survival in healthy older adults: A prospective cohort study"],"prefix":"10.1111","volume":"147","author":[{"given":"Greg","family":"Roebuck","sequence":"first","affiliation":[{"name":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine Deakin University, and Barwon Health  Geelong Victoria Australia"},{"name":"Phoenix Australia \u2013 Centre for Posttraumatic Mental Health, Department of Psychiatry University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Lotfaliany","sequence":"additional","affiliation":[{"name":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine Deakin University, and Barwon Health  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Agustini","sequence":"additional","affiliation":[{"name":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine Deakin University, and Barwon Health  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Forbes","sequence":"additional","affiliation":[{"name":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine Deakin University, and Barwon Health  Geelong Victoria Australia"},{"name":"Department of Psychiatry University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-7211","authenticated-orcid":false,"given":"Mohammadreza","family":"Mohebbi","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McNeil","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L.","family":"Woods","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Reid","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"School of Population Health Curtin University  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research University of Tasmania  Hobart Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj C.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Ryan","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"Newman","sequence":"additional","affiliation":[{"name":"School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Owen","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanne","family":"Freak\u2010Poli","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Stocks","sequence":"additional","affiliation":[{"name":"Discipline of General Practice, Faculty of Health and Medical Sciences University of Adelaide  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