{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:14Z","timestamp":1772159954829,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Patients with bipolar disorder spend most of their clinical lifetime in the depressive phase of their illness. However, antidepressants are discouraged in the treatment of bipolar depression due to concerns over manic induction and drug ineffectiveness. Some reports suggest that monoamine oxidase inhibitors (MAOIs) may be safe and effective compared to other antidepressants in treating bipolar depression. The present study compared the safety and effectiveness of MAOI therapy in patients with bipolar versus unipolar depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from approximately 2500 clinical research charts of patients treated with MAOI therapy at a university mood disorder clinic between 1983 and 2015. A mixed\u2010effects model was created with patient entered as the random effect. The model included the primary diagnosis (i.e., either unipolar or bipolar depression) and other clinical covariates as fixed\u2010effect predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with bipolar depression demonstrated lower post\u2010treatment clinical global impressions\/severity scores versus patients with unipolar depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04). Neither group demonstrated a full syndromal manic or hypomanic episode. A higher proportion of patients with bipolar depression reported myoclonic tics and tremors, which may have resulted from concomitant lithium use. Amongst the covariates, only the number of prior antidepressant trials predicted poorer outcomes from MAOI therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MAOIs may be more effective\u2014and as safe\u2014for patients with bipolar depression versus unipolar depression. Future studies should explore this possible advantage using a larger sample size.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13518","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T12:06:15Z","timestamp":1667563575000},"page":"198-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness and safety of monoamine oxidase inhibitor treatment for bipolar depression versus unipolar depression: An exploratory case cohort study"],"prefix":"10.1111","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-6647","authenticated-orcid":false,"given":"Thomas T.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Psychology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay D.","family":"Amsterdam","sequence":"additional","affiliation":[{"name":"Depression Research Unit, Department of Psychiatry, Perelman School of Medicine University of Pennsylvania School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1906193"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.6.530"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.3.261"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097966"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.12.1322"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(97)00109-1"},{"key":"e_1_2_8_9_1","unstructured":"NICE.Common Mental Health Disorders: The NICE Guideline on Identification and Pathways to Care;2011."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09r05385gre"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.9.1537"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01514.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.03.030"},{"key":"e_1_2_8_14_1","first-page":"64","article-title":"Revisiting the effectiveness of standard antidepressants in bipolar disorder: are monoamine oxidase inhibitors superior?","volume":"42","author":"Mallinger AG","year":"2009","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n1002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852922000906"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.01.021"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.03.028"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.06.011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0097-3"},{"key":"e_1_2_8_21_1","volume-title":"Use of High Dose Tranylcypromine in Resistant Depression","author":"Amsterdam JD","year":"1991"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2007.58.1.85"},{"key":"e_1_2_8_23_1","unstructured":"Diagnostic and statistical manual of mental disorders: DSM\u2010III;1980."},{"key":"e_1_2_8_24_1","unstructured":"Diagnostic and statistical manual of mental disorders: DSM\u2010III\u2010R;1987."},{"key":"e_1_2_8_25_1","volume-title":"Diagnostic and statistical manual of mental disorders: DSM\u2010IV","author":"Bell CC","year":"1994"},{"key":"e_1_2_8_26_1","first-page":"1","article-title":"Methodological considerations for the study of treatment\u2010resistant depression","volume":"2","author":"Nierenberg A","year":"1991","journal-title":"Adv Neuropsychiatry Psychopharmacol"},{"key":"e_1_2_8_27_1","first-page":"39","article-title":"Treatment\u2010resistant depression: definition and treatment approaches","volume":"51","author":"Nierenberg A","year":"1990","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_8_28_1","first-page":"534","volume-title":"ECDEU Assessment Manual for Psychopharmacology","author":"Guy W","year":"1976"},{"key":"e_1_2_8_29_1","unstructured":"FawcettJ EpsteinP FiesterSJ ElkinI AutryJH.Clinical management\u2014imipramine\/placebo administration manual. NIMH Treatment of Depression Collaborative Research Program. Psychopharmacol Bull.1987;23:309\u2010324."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1994.tb05705.x"},{"key":"e_1_2_8_31_1","volume-title":"Methodological Considerations for the Study of Treatment Resistant Depression","author":"Nierenberg AA","year":"1991"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n0308"},{"key":"e_1_2_8_33_1","volume-title":"Fitting Linear Mixed\u2010Effects Models Using lme4","author":"Bates D","year":"2014"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.013045"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098214011426594"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000409"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-016-0068-y"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000226611"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.11.1905"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.07.007"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12442"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001049"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13020185"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acps.13518","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T07:08:59Z","timestamp":1692428939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.13518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,12]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/acps.13518"],"URL":"https:\/\/doi.org\/10.1111\/acps.13518","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ACPS.13518\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13518\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13518\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13518\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13518\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13518\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,12]]},"assertion":[{"value":"2022-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}