{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:14Z","timestamp":1772159954841,"version":"3.50.1"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23MH115184"],"award-info":[{"award-number":["K23MH115184"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH105662"],"award-info":[{"award-number":["R01MH105662"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Behavioral features of anorexia nervosa (AN) suggest abnormalities in reward and habit. Neuroimaging evidence suggests morphometric and functional perturbations within these circuits, although fewer studies have assessed white matter characteristics in AN, and no studies to date have assessed white matter microstructure in AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this brain imaging study, 29 female adolescents with partially or fully weight\u2010restored AN and 27 healthy controls, all between 10 and 19\u2009years, underwent whole\u2010brain multi\u2010shell diffusion tensor imaging. Utilizing neurite orientation dispersion and density imaging methods, we investigated group differences in white matter neurite density, orientation dispersion, and myelin density in tracts between prominent nodes of the reward circuit (ventral tegmental area (VTA) to nucleus accumbens (NAcc)) and the habit circuit (sensory motor area [SMA] to putamen).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Findings revealed reduced neurite (\n                      <jats:italic>F<\/jats:italic>\n                      \u00a0=\u00a05.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.027) and myelin density (\n                      <jats:italic>F<\/jats:italic>\n                      \u00a0=\u00a05.39,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.025) in the left VTA\u2010NAcc tract, and reduced orientation dispersion in the left (\n                      <jats:italic>F<\/jats:italic>\n                      \u00a0=\u00a07.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011) and right (\n                      <jats:italic>F<\/jats:italic>\n                      \u00a0=\u00a06.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012) VTA\u2010NAcc tract. There were no significant group differences in the SMA\u2010putamen tract. Significant relationships, after corrections, were not evident between tract microstructure and reward responsiveness, compulsive behaviors, illness duration, or BMI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adolescents with AN exhibit less dense, undermyelinated, and less dispersed white matter tracts connecting prominent reward system nodes, which could potentially signify underutilization of this part of the reward circuit. These results provide a detailed examination of white matter microstructure in tracts underlying instrumental behavioral phenotypes contributing to illness in AN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13521","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T22:38:25Z","timestamp":1668465505000},"page":"134-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["White matter microstructure in habit and reward circuits in anorexia nervosa: Insights from a neurite orientation dispersion and density imaging study"],"prefix":"10.1111","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5588-2915","authenticated-orcid":false,"given":"Stuart B.","family":"Murray","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-3588","authenticated-orcid":false,"given":"Ryan P.","family":"Cabeen","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3574-0538","authenticated-orcid":false,"given":"Kay","family":"Jann","sequence":"additional","affiliation":[{"name":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Tadayonnejad","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences University of California  Los Angeles California USA"},{"name":"Computation &amp; Neural Systems program California Institute of Technology  Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9134-317X","authenticated-orcid":false,"given":"Michael","family":"Strober","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0391-345X","authenticated-orcid":false,"given":"Jamie D.","family":"Feusner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences University of California  Los Angeles California USA"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2019.04.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-016-0106-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2342"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23645"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-200009000-00001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617712000446"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23644"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-018-0928-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23265"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eatbeh.2017.03.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2012.01.036"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.02.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2014.07.007"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.2151"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.1580"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.01.003"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07040575"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.09.024"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24402"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.07.004"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2019.01.011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49884-6"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v6.i1.177"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95300-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.806327"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2021.111427"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.072"},{"key":"e_1_2_9_30_1","volume-title":"International Symposium on Magnetic Resonance in Medicine Workshop","author":"Campbell JSW","year":"2013"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971006)386:4<661::AID-CNE11>3.0.CO;2-N"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.6.558"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519885107"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.043"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx022.077"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22872"},{"key":"e_1_2_9_37_1","first-page":"26","volume-title":"Pre\u2010surgical high\u2010resolution microstructural imaging in mesial temporal lobe epilepsy","author":"Sepehrband F","year":"2018"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05305whi"},{"key":"e_1_2_9_39_1","first-page":"317","volume-title":"Binge Eating: Nature Assessment and Treatment","author":"Fairburn CG","year":"1993"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/1054-139X(93)90004-9"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.67.2.319"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20605"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_9_44_1","first-page":"1","article-title":"Advanced normalization tools (ANTS)","volume":"2","author":"Avants BB","year":"2009","journal-title":"Insight J"},{"key":"e_1_2_9_45_1","first-page":"12","article-title":"Quantitative imaging toolkit: software for interactive 3D visualization, data exploration, and computational analysis of neuroimaging datasets","author":"Cabeen RP","year":"2018","journal-title":"ISMRM\u2010ESMRMB Abstr"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22003"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.019"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.09.073"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.028"},{"key":"e_1_2_9_51_1","unstructured":"CabeenR SepehrbandF TogaA. (2019):Rapid and accurate NODDI parameter estimation with the spherical mean technique. Paper presented at: Proceedings at International Society for Magnetic Resonance in Medicine (ISMRM) 3363."},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.008"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.63"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.11.061"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27471"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(82)90016-9"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.10.008"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06113-x"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90065-9"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.40.4.551"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb01683.x"},{"key":"e_1_2_9_64_1","first-page":"3","volume-title":"Resional Development of the Brain in Early Life, A","author":"Yakovlev PL","year":"1967"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0765-x"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.03.068"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-021-00456-4"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2565"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05176blu"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.10.013"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.174"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.12.035"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01405-8"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acps.13521","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T07:09:37Z","timestamp":1692428977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.13521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/acps.13521"],"URL":"https:\/\/doi.org\/10.1111\/acps.13521","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.07.20.22277868","asserted-by":"object"}]},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]},"assertion":[{"value":"2022-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}