{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:05Z","timestamp":1787013785988,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lithium augmentation (LA) of antidepressants is a first\u2010line therapy option for treatment\u2010resistant depression (TRD). Nevertheless, it is rarely used in geriatric patients mostly because of the fear of kidney toxicity. The purpose of this study is to investigate estimated glomerular filtration rate (eGFR) changes and number of acute kidney injuries (AKI) using LA in geriatric compared with non\u2010geriatric patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a prospective multicenter cohort study, eGFR changes were measured in 201 patients with unipolar depression (\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>age\u226565years<\/jats:sub>\n                      \u00a0=\u200929;\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>age&lt;65years<\/jats:sub>\n                      \u00a0=\u2009172) at baseline and over 2\u20136\u2009weeks of LA. We used linear mixed models to investigate changes in eGFR upon LA and assessed the number of AKIs, according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both age groups showed a significant eGFR decline over the course of treatment with lower eGFR in geriatric patients. The lithium serum level (interpretable as \u201ceffect of LA\u201d) had a significant effect on eGFR decline. Both effects (age group and lithium serum level) on eGFR decline did not influence each other, meaning the effect of LA on eGFR decline did not differ between age groups. Two AKIs were observed in the geriatric age group when serum lithium levels exceeded the therapeutic range of &gt;0.8\u2009mmol\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first study investigating eGFR change and AKI upon LA for TRD in geriatric compared with non\u2010geriatric patients. Our data suggest that LA, as an effective treatment option in geriatric patients, should be closely monitored to avoid AKIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13531","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T01:14:42Z","timestamp":1672449282000},"page":"267-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute effects of lithium augmentation on the kidney in geriatric compared with non\u2010geriatric patients with treatment\u2010resistant depression"],"prefix":"10.1111","volume":"147","author":[{"given":"Sarah Luise","family":"Osterland","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin 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University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Behr","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics Brandenburg Medical School Theodor Fontane  Neuruppin Germany"},{"name":"Faculty of Health Sciences Brandenburg Joint Faculty of the University of Potsdam, Brandenburg University of Technology Cottbus\u2010Senftenberg and Brandenburg Medical School  Potsdam Germany"},{"name":"Research Department of Experimental and Molecular Psychiatry, Department of Psychiatry and Psychotherapy Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronja","family":"M\u00fcller\u2010Mertel","sequence":"additional","affiliation":[{"name":"Department of Psychology \u2010 Clinical Psychology and Psychotherapy Brandenburg Medical School Theodor Fontane  Neuruppin 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