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This multimodal neuroimaging meta\u2010analysis aimed to estimate common and specific alterations in SUD patients by combining information from all available studies of spontaneous functional activity and gray matter volume (GMV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A whole\u2010brain meta\u2010analysis on resting\u2010state functional imaging and VBM studies was conducted using the Seed\u2010based\n                      <jats:italic>d<\/jats:italic>\n                      Mapping with Permutation of Subject Images (SDM\u2010PSI) software, followed by multimodal overlapping to comprehensively investigate function and structure of the brain in SUD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this meta\u2010analysis, 39 independent studies with 47 datasets related to resting\u2010state functional brain activity (1444 SUD patients; 1446 healthy controls [HCs]) were included, as well as 77 studies with 89 datasets for GMV (3457 SUD patients; 3774 HCs). Patients with SUD showed the decreased resting\u2010state functional brain activity in the bilateral anterior cingulate cortex\/medial prefrontal cortex (ACC\/mPFC). For the VBM meta\u2010analysis, patients with SUD showed the reduced GMV in the bilateral ACC\/mPFC, insula, thalamus extending to striatum, and left sensorimotor cortex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This multimodal meta\u2010analysis exhibited that SUD shows common impairment in both function and structure in the ACC\/mPFC, suggesting that the deficits in functional and structural domains could be correlated together. In addition, a few regions exhibited only structural impairment in SUD, including the insula, thalamus, striatum, and sensorimotor areas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13539","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T23:56:22Z","timestamp":1676937382000},"page":"345-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Functional and structural brain abnormalities in substance use disorder: A multimodal meta\u2010analysis of neuroimaging studies"],"prefix":"10.1111","volume":"147","author":[{"given":"Hong","family":"Yan","sequence":"first","affiliation":[{"name":"Medical Imaging Center First Affiliated Hospital of Jinan University  Guangzhou China"},{"name":"Institute of Molecular and Functional Imaging Jinan University  Guangzhou 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