{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:45:01Z","timestamp":1787316301510,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>High relapse rates are observed after electroconvulsive therapy (ECT) for major depression. Identifying patients who are at increased risk for relapse to intensify their treatment regimen post\u2010ECT might reduce relapse rates. We aimed to determine clinical characteristics that are associated with relapse within 2\u2009years after successful ECT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who remitted to ECT in a randomised controlled trial comparing adjuvant nortriptyline and placebo during a course of bilateral ECT were followed\u2010up prospectively for 1 year with open\u2010label nortriptyline (Dutch Trial Register NTR5579). Second\u2010year follow\u2010up data were collected retrospectively. Thirty\u2010four patients were included in this follow\u2010up cohort. To examine the association between clinical characteristics and the risk of relapse, unadjusted hazard ratios (HRs) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 2\u2009years post\u2010ECT, the overall relapse rate was 50%, and the HRs for relapse in patients with psychotic features, a higher severity of depression, and medication resistance prior to ECT were 0.33 (CI 0.12\u20130.89;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029), 0.88 (CI 0.80\u20130.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), and 4.48 (CI 1.28\u201315.73,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), respectively. No effect was found for age, sex or episode duration on the relapse rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Depressed patients with psychotic features, with higher symptom severity and without medication resistance prior to ECT have a significantly decreased risk of relapse after successful ECT. A sustained remission rate of 50% over 2\u2009years in patients with severe major depression who were treated with nortriptyline monotherapy after successful ECT is encouraging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13542","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T05:35:26Z","timestamp":1679290526000},"page":"561-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical characteristics associated with relapse 2\u2009years after electroconvulsive therapy for major depression"],"prefix":"10.1111","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7514-0946","authenticated-orcid":false,"given":"Esther M.","family":"Pluijms","sequence":"first","affiliation":[{"name":"Department of Psychiatry Erasmus University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6469-430X","authenticated-orcid":false,"given":"Poul T.","family":"Vinther","sequence":"additional","affiliation":[{"name":"Department of Intensive Home Treatment Antes Psychiatric Institute (part of Parnassia Group)  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4455-6492","authenticated-orcid":false,"given":"Astrid M.","family":"Kamperman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Erasmus University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6611-6597","authenticated-orcid":false,"given":"Tom K.","family":"Birkenh\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Erasmus University Medical Centre  Rotterdam the Netherlands"},{"name":"Department of Psychiatry Collaborative Antwerp Psychiatric Research Institute, University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12705-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.149"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13331"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCT.0b013e31826ea8c4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2019.37"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.12.028"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0115"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.07.039"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199004000-00004"},{"issue":"2","key":"e_1_2_11_11_1","first-page":"80","article-title":"A 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