{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:39:56Z","timestamp":1790372396968,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Schizophrenia spectrum disorders (SSD) comprise a group of related mental disorders, which share clinical features and common genetic disposition, but it is unknown if there is a diagnostic transition between these disorders over time. We aimed to study the incidence at the first SSD diagnosis between 2000 and 2018, defined as schizophrenia, schizotypal or schizoaffective disorder, and the early diagnostic transition between these disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using Danish nationwide healthcare registers, we identified all individuals aged 15\u201364\u2009years during the period from 2000 to 2018 in Denmark and calculated the yearly incidence rates for the specific SSDs. We studied the diagnostic pathways from the first ever diagnosis of an SSD across the subsequent two treatment courses with an SSD diagnosis to evaluate early diagnostic stability, and explore potential changes over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 21,538 patients, yearly incidence rates per 10,000 individuals were similar during the observation period for schizophrenia (2000: 1.8; 2018: 1.6), lower for schizoaffective disorder (2000: 0.3; 2018: 0.1) and increasing for schizotypal disorder (2000: 0.7; 2018: 1.3). Among the subgroup of 13,417 individuals with three separate treatment courses, early diagnostic stability was present among 89.9% which differed between the disorders (schizophrenia: 95.4%; schizotypal disorder: 78.0%; schizoaffective disorder: 80.5%). Among 1352 (10.1%) experiencing an early diagnostic transition, 398 (3.0%) were diagnosed with schizotypal disorder after a schizophrenia or schizoaffective disorder diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides comprehensive incidence rates for SSDs. The majority of patients experienced early diagnostic stability, but sizable proportions of people with initial schizophrenia or schizoaffective disorder are subsequently diagnosed with schizotypal disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13565","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T03:13:50Z","timestamp":1685157230000},"page":"190-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Schizophrenia spectrum disorders in Denmark between 2000 and 2018: Incidence and early diagnostic transition"],"prefix":"10.1111","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5121-1287","authenticated-orcid":false,"given":"Ole","family":"K\u00f6hler\u2010Forsberg","sequence":"first","affiliation":[{"name":"Psychosis Research Unit Aarhus University Hospital \u2013 Psychiatry  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8235-7497","authenticated-orcid":false,"given":"Sussie","family":"Antonsen","sequence":"additional","affiliation":[{"name":"iPSYCH The Lundbeck Initiative for Integrated Research in Psychiatry  Aarhus Denmark"},{"name":"Centre for Integrated Register\u2010based Research (CIRRAU) Aarhus University  Aarhus Denmark"},{"name":"National Centre for Register\u2010Based Research (NCRR) Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-8533","authenticated-orcid":false,"given":"Carsten B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"iPSYCH The Lundbeck Initiative for Integrated Research in Psychiatry  Aarhus Denmark"},{"name":"Centre for Integrated Register\u2010based Research (CIRRAU) Aarhus University  Aarhus Denmark"},{"name":"National Centre for Register\u2010Based Research (NCRR) Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preben Bo","family":"Mortensen","sequence":"additional","affiliation":[{"name":"iPSYCH The Lundbeck Initiative for Integrated Research in Psychiatry  Aarhus Denmark"},{"name":"Centre for Integrated Register\u2010based Research (CIRRAU) Aarhus University  Aarhus Denmark"},{"name":"National Centre for Register\u2010Based Research (NCRR) Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-6068","authenticated-orcid":false,"given":"John J.","family":"McGrath","sequence":"additional","affiliation":[{"name":"National Centre for Register\u2010Based Research (NCRR) Aarhus University  Aarhus Denmark"},{"name":"Queensland Centre for Mental Health Research The Park Centre for Mental Health  Wacol Queensland Australia"},{"name":"Queensland Brain Institute University of Queensland  St Lucia Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Mors","sequence":"additional","affiliation":[{"name":"Psychosis Research Unit Aarhus University Hospital \u2013 Psychiatry  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"iPSYCH The Lundbeck Initiative for Integrated Research in Psychiatry  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1979.01780010023001"},{"key":"e_1_2_9_3_1","volume-title":"The ICD\u201010 Classification of Mental and Behavioural Disorders. 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