{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:17:02Z","timestamp":1788999422069,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Antipsychotics have conflicting data with respect to obsessive\u2013compulsive disorder\/symptoms (OCD\/OCS), with some reporting causality and some reporting treatment benefits. This pharmacovigilance study aimed to investigate reporting of OCD\/OCS in association with the use of antipsychotics in comparison to one another, as well as treatment failure using data derived from the FDA Adverse Event Reporting System (FAERS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from January 1st, 2010 to December 31st, 2020 on suspected adverse drug reactions (ADRs) including OCD\/OCS was obtained. The information component (IC) was used to determine a disproportionality signal, and reporting odds ratio (ROR) calculations were performed via intra\u2010class analyses to discern differences between the evaluated antipsychotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1454 OCD\/OCS cases were utilized in IC and ROR calculations and 385,972 suspected ADRs were used as non\u2010cases. A significant disproportionality signal was seen with all second generation antipsychotics. Relative to other antipsychotics, only aripiprazole had a significant ROR of 23.87 (95% CI: 21.01\u201327.13;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The ROR for antipsychotic treatment failure in those with OCD\/OCS was highest with aripiprazole, and lowest with risperidone and quetiapine. Sensitivity analyses were largely in favor of the primary findings. Our analysis appears to implicate the 5\u2010HT\n                      <jats:sub>1A<\/jats:sub>\n                      receptor or an imbalance between this receptor and the D\n                      <jats:sub>2<\/jats:sub>\n                      \u2010receptor in antipsychotic treatment\u2010emergent OCD\/OCS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In contrast to prior reports noting clozapine as the antipsychotic most commonly associated with de novo or exacerbated OCD\/OCS, this pharmacovigilance study found aripiprazole was most frequently reported for this adverse effect. While these findings from FAERS offer a unique perspective on OCD\/OCS with different antipsychotic agents, due to the inherent limitations of pharmacovigilance studies they should ideally be validated through alternative prospective research studies involving direct comparisons of antipsychotic agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13567","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T04:17:22Z","timestamp":1684297042000},"page":"32-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Antipsychotics and obsessive\u2013compulsive disorder\/obsessive\u2013compulsive symptoms: A pharmacovigilance study of the\n                    <scp>FDA<\/scp>\n                    adverse event reporting system"],"prefix":"10.1111","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-3785","authenticated-orcid":false,"given":"Bradley 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