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However, there is no effective treatment targeting cognition in BD. A key reason for the lack of pro\u2010cognitive interventions is the limited insight into the brain correlates of cognitive impairments in these patients. This is the first study investigating the resting\u2010state neural underpinnings of cognitive impairments in different neurocognitive subgroups of patients with BD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with BD in full or partial remission and healthy controls (final sample of <jats:italic>n<\/jats:italic>\u2009=\u2009144 and <jats:italic>n<\/jats:italic>\u2009=\u200950, respectively) underwent neuropsychological assessment and resting\u2010state functional magnetic resonance imaging. We classified the patients into cognitively impaired (<jats:italic>n<\/jats:italic>\u2009=\u200983) and cognitively normal (<jats:italic>n<\/jats:italic>\u2009=\u200961) subgroups using hierarchical cluster analysis of the four cognitive domains. We used independent component analysis (ICA) to investigate the differences between the neurocognitive subgroups and healthy controls in resting\u2010state functional connectivity (rsFC) in the default mode network (DMN), executive central network (ECN), and frontoparietal network (FPN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cognitively impaired patients displayed greater positive rsFC within the DMN and less negative rsFC within the ECN than healthy controls. Across cognitively impaired patients, lower positive connectivity within DMN and lower negative rsFC within ECN correlated with worse global cognitive performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cognitive impairments in BD seem to be associated with a <jats:italic>hyper<\/jats:italic>\u2010connectivity within the DMN, which may explain the failure to suppress task\u2010irrelevant DMN activity during the cognitive performance, and blunted anticorrelation in the ECN. Thus, aberrant connectivity within the DMN and ECN may serve as brain targets for pro\u2010cognitive interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13615","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T05:01:25Z","timestamp":1694235685000},"page":"570-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Aberrant resting\u2010state functional connectivity underlies cognitive and functional impairments in remitted patients with bipolar disorder"],"prefix":"10.1111","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6778-2316","authenticated-orcid":false,"given":"Lydia","family":"Fortea","sequence":"first","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS) Fundaci\u00f3 Cl\u00ednic per la Recerca Biom\u00e8dica (FCRB)  Barcelona Spain"},{"name":"Department of Medicine, Institute of Neuroscience University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander T.","family":"Ysb\u00e6k\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Copenhagen Affective disorder Research Center (CADIC), Psychiatric Centre Copenhagen Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Neurocognition and Emotion in Affective Disorders Centre (NEAD), Department of Psychology University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Macoveanu","sequence":"additional","affiliation":[{"name":"Copenhagen Affective disorder Research Center (CADIC), Psychiatric Centre Copenhagen Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff Zarp","family":"Petersen","sequence":"additional","affiliation":[{"name":"Copenhagen Affective disorder Research Center (CADIC), Psychiatric Centre Copenhagen Copenhagen University 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