{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:55:16Z","timestamp":1775847316096,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>According to guidelines, psychotic depression should be treated with both antipsychotics and antidepressants, but current practice is largely unknown. We investigated the prevalence of antipsychotic and antidepressant use in first\u2010episode psychotic depression and factors related to antipsychotic use after the diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified individuals aged 16\u201365 with a first\u2010episode diagnosis of psychotic depression (ICD\u201010 codes F32.3, F33.3) from nationwide data linkage of Finnish healthcare and population registers during 2000\u20132018. Point prevalence was measured as 2\u2010week time windows every 3\u2009months, investigating whether the individual had a modeled drug use period ongoing during the window or not, censoring to death and end of data linkage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 18,490 individuals (58.0% women; mean age 39.9\u2009years, standard deviation 14.7). The prevalence of use for antidepressants (75.0%), antipsychotics (56.4%), and both (50.0%) were highest at 3\u2009months after the diagnosis. The prevalence declined to 51.8%, 34.1%, and 28.7%, respectively, at 3\u2009years after the diagnosis. In a logistic regression analysis, younger age (adjusted odds ratio\u2009&lt;\u200925 vs. \u226555, 0.82 [95% confidence interval 0.73\u20130.91]), eating disorders (0.78 [0.66\u20130.92]), substance use disorders (0.80 [0.73\u20130.87]), and occupational inactivity (0.80 [0.73\u20130.87]) were associated with decreased odds of using antipsychotics at 3\u2009months after diagnosis. Increased odds were found for diagnosis from inpatient care (1.74 [1.62\u20131.86]), and later year of cohort entry (2010\u20132014 vs. 2000\u20132004, 1.56 [1.42\u20131.70]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At most, half of the individuals with newly diagnosed psychotic depression used both antidepressants and antipsychotics. This likely has a negative impact on treatment success.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13616","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T05:29:35Z","timestamp":1694064575000},"page":"416-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of antipsychotics and antidepressants in first\u2010episode psychotic depression: A nationwide register\u2010based study"],"prefix":"10.1111","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-4059","authenticated-orcid":false,"given":"A.","family":"Hamina","sequence":"first","affiliation":[{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital University of Eastern Finland  Kuopio Finland"},{"name":"Norwegian Centre for Addiction Research (SERAF), Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Palj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tanskanen","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"L\u00e4hteenvuo","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital University of Eastern Finland  Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tiihonen","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital University of Eastern Finland  Kuopio Finland"},{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3281-934X","authenticated-orcid":false,"given":"H.","family":"Taipale","sequence":"additional","affiliation":[{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital University of Eastern Finland  Kuopio Finland"},{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511348"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717002501"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2022.140"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-018-0207-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.10.035"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-018-9388-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0813"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(93)90063-P"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pra.0000407968.57475.ab"},{"key":"e_1_2_9_11_1","unstructured":"GelenbergAJ FreemanMP MarkowitzJC et al.Practice Guideline for the Treatment of Patients with Major Depressive Disorder (Revision).2010."},{"key":"e_1_2_9_12_1","unstructured":"National Institute for Healthcare and Clinical Excellence.Depression in adults: treatment and management."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004044.pub5"},{"key":"e_1_2_9_14_1","unstructured":"WHO Collaborating Center for Drug Statistics Methodology.Norwegian Institute of Public Health. 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