{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:27:03Z","timestamp":1791685623363,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PI21\/00169"],"award-info":[{"award-number":["PI21\/00169"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PI21\/00787"],"award-info":[{"award-number":["PI21\/00787"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PI18\/00805"],"award-info":[{"award-number":["PI18\/00805"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006751","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2017131"],"award-info":[{"award-number":["2017131"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1156072"],"award-info":[{"award-number":["1156072"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bipolar disorder (BD) is a chronic and recurrent disease characterized by acute mood episodes and periods of euthymia. The available literature postulates that a biphasic dysregulation of mitochondrial bioenergetics might underpin the neurobiology of BD. However, most studies focused on inter\u2010subject differences rather than intra\u2010subject variations between different mood states. To test this hypothesis, in this preliminary proof\u2010of\u2010concept study, we measured in vivo mitochondrial respiration in patients with BD during a mood episode and investigated differences compared to healthy controls (HC) and to the same patients upon clinical remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This longitudinal study recruited 20 patients with BD admitted to our acute psychiatric ward with a manic (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) or depressive (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095) episode, and 10 matched HC. We assessed manic and depressive symptoms using standardized psychometric scales. Different mitochondrial oxygen consumption rates (OCRs: Routine, Leak, electron transport chain [ETC], Rox) were assessed during the acute episode (T0) and after clinical remission (T1) using high\u2010resolution respirometry at 37\u00b0C by polarographic oxygen sensors in a two\u2010chamber Oxygraph\u20102k system in one million of peripheral blood mononuclear cells (PMBC). Specific OCRs were expressed as mean\u2009\u00b1\u2009SD in picomoles of oxygen per million cells. Significant results were adjusted for age, sex, and body mass index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The longitudinal analysis showed a significant increase in the maximal oxygen consumption capacity (ETC) in clinical remission (25.7\u2009\u00b1\u200916.7) compared to the acute episodes (19.1\u2009\u00b1\u200911.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025), and was observed separately for patients admitted with a manic episode (29.2\u2009\u00b1\u200918.9 in T1, 22.3\u2009\u00b1\u200911.9 in T0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.076), and at a trend\u2010level for patients admitted with a depressive episode (15.4\u2009\u00b1\u20093.9 in T1 compared to 9.4\u2009\u00b1\u20093.2 in T0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.107). Compared to HC, significant differences were observed in ETC in patients with a bipolar mood episode (\n                      <jats:italic>H<\/jats:italic>\n                      \u2009=\u200911.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Individuals with bipolar depression showed lower ETC than those with a manic episode (\n                      <jats:italic>t<\/jats:italic>\n                      \u2009=\u2009\u22123.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Also, significant differences were observed in ETC rates between HC and bipolar depression (\n                      <jats:italic>Z<\/jats:italic>\n                      \u2009=\u20091.000,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bioenergetic and mitochondrial dysregulation could be present in both manic and depressive phases in BD and, importantly, they may restore after clinical remission. These preliminary results suggest that mitochondrial respiratory capacity could be a biomarker of illness activity and clinical response in BD. Further studies with larger samples and similar approaches are needed to confirm these results and identify potential biomarkers in different phases of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13635","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T19:49:38Z","timestamp":1701287378000},"page":"52-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Reduced mitochondrial respiratory capacity in patients with acute episodes of bipolar disorder: Could bipolar disorder be a state\u2010dependent mitochondrial disease?"],"prefix":"10.1111","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9474-6473","authenticated-orcid":false,"given":"Anna","family":"Gim\u00e9nez\u2010Palomo","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology, Institute of Neuroscience Hospital Cl\u00ednic de Barcelona  Barcelona 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