{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:39Z","timestamp":1772159979366,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T00:00:00Z","timestamp":1702166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Offspring of parents with schizophrenia spectrum disorders (SSD) have an increased risk of neurodevelopmental disturbances. However, the ability to provide very early interventions to support these children and their families requires profound knowledge regarding characteristic features of both the parents and their offspring. Information on this subject is currently sparse. The aim of the present study is to investigate clinical and sociodemographic variables in offspring in the age range of 0\u20133\u2009years of mothers diagnosed with SSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study is descriptive with a cross\u2010sectional design and includes parent\u2010child dyads consisting of mothers diagnosed with SSD (ICD\u201010: F20\u201029) and their offspring aged 0\u20103 years, who were referred for examination and intervention at the infant and toddler psychiatric units, at the Mental Health Services, Capital Region, Copenhagen University Hospitals in two locations (Bispebjerg and Glostrup). Clinical and sociodemographic data were extracted from the Copenhagen \u201cInfant Psychiatric Database\u201d and processed by descriptive analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 95 parent\u2013child dyads considered for the study population, 85 were included. 27.8% of the mothers had psychiatric comorbidities, and 18.9% of the fathers had a psychiatric diagnosis at the time of investigation. Of the children, 89.7% were born full term (\u226537th week) and most of them had a birth weight of \u22652500\u2009g (81.8%). Of the mothers, 50% had experienced pregnancy complications of varying severity. Birth complications were seen in 62.9% of the dyads. Psychopathology was identified in 50% of the children at age 0\u20133\u2009years, and 62.2% of the parent\u2013child dyads appeared to have an affected relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results show widespread psychopathology in offspring aged 0\u20133\u2009years of mothers with SSD. Moreover, several psychosocial stressors, clinical parental features, and relational disturbances are identified. These results contribute to a better understanding and identification of early risk markers of long\u2010term psychopathology in this infant patient group, and hence serve as potential targets for early interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13641","type":"journal-article","created":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T22:54:15Z","timestamp":1702248855000},"page":"147-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and sociodemographic features in offspring aged 0\u20133\u2009years of mothers with schizophrenia spectrum disorders. A descriptive cross\u2010sectional study"],"prefix":"10.1111","volume":"149","author":[{"given":"Emilie","family":"Edvardsen","sequence":"first","affiliation":[{"name":"Child and Adolescent Mental Health Center Copenhagen University Hospital \u2013 Mental Health Services CPH  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mala","family":"Moszkowicz","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Copenhagen University Hospital \u2013 Mental Health Services CPH  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Lise","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Copenhagen University Hospital \u2013 Psychiatry Region Zealand Denmark  Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michella","family":"Heinrichsen","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Copenhagen University Hospital \u2013 Mental Health Services CPH  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Katrine","family":"Pagsberg","sequence":"additional","affiliation":[{"name":"Child and Adolescent Mental Health Center Copenhagen University Hospital \u2013 Mental Health Services CPH  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx094"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-195701000-00001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707009944"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.185.1.11"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000076"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.03.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt114"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2015.04.006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30103-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(22)00402-3"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.6.1030"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.01.005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719001089"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-015-0692-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2007.09.001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867419864427"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13281"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a007080"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2006.01618.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0021-9630.2003.00316.x"},{"key":"e_1_2_10_23_1","volume-title":"The ICD\u201010 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines","author":"World Health Organization","year":"1992"},{"key":"e_1_2_10_24_1","volume-title":"Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Childhood: Revised Edition (DC: 0\u20103R)","author":"Zero to three","year":"2005"},{"key":"e_1_2_10_25_1","volume-title":"Bayley Scales of Infant and Toddler Development \u2013 Third Edition","author":"Nancy Bayley","year":"2006"},{"key":"e_1_2_10_26_1","volume-title":"The Parent\u2010Child Early Relational Assessment (PCERA)","author":"Roseanne Clark","year":"2015"},{"key":"e_1_2_10_27_1","volume-title":"Autism Diagnostic Observation Schedule, Second Edition (ADOS\u20102). Modules 1\u20134","author":"Hus V","year":"2012"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1753-2000-7-17"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20527"},{"key":"e_1_2_10_30_1","volume-title":"Socio\u2010economy, Home Environment and Accumulated Disadvantages Amongst Children of Parents with Schizophrenia or Bipolar Disorder, in Department of Clinical Medicine, Faculty of Health and Medical Sciences","author":"Krantz MF","year":"2021"},{"key":"e_1_2_10_31_1","volume-title":"Age Seven and Being at Familial High Risk for Severe Mental Illness \u2013 Emotion Regulation, Executive Functions, and Psychopathology, in Department of Clinical Medicine, Faculty of Health and Medical Sciences","author":"Spang KS","year":"2020"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13057"},{"issue":"3","key":"e_1_2_10_33_1","first-page":"S26","article-title":"Obstetric and neonatal outcomes of pregnant women with severe mental illness at a specialist antenatal clinic","volume":"199","author":"Nguyen TN","year":"2013","journal-title":"Med J Aust"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.07.037"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08931"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2016.07.776"},{"key":"e_1_2_10_37_1","first-page":"227","article-title":"The Finnish adoptive family study of schizophrenia","volume":"58","author":"Tienari P","year":"1985","journal-title":"Yale J Biol Med"},{"key":"e_1_2_10_38_1","volume-title":"F\u00f8dselsstatistik MIPAC 2020\u2014F\u00f8dsler i Danmark 1997\u20132017","author":"Juhl M","year":"2020"},{"key":"e_1_2_10_39_1","unstructured":"Nyf\u00f8dte og f\u00f8dsler (1997\u2010); 2022.http:\/\/www.esundhed.dk\/"},{"key":"e_1_2_10_40_1","unstructured":"Low\u2010birthweight babies (% of births)\u2013Denmark.https:\/\/data.worldbank.org\/indicator\/SH.STA.BRTW.ZS?end=2015&locations=DK&start=2000&view=chart"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00234-0"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt239"},{"key":"e_1_2_10_43_1","unstructured":"\u2018Tobak og graviditet\u2019; 2003. National Board of Health in Denmark."},{"key":"e_1_2_10_44_1","volume-title":"Sundhed blandt borgere med etnisk minoritetsbaggrund \u00a9Sundhedsstyrelsen","author":"Jezek AH","year":"2023"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0021026"},{"key":"e_1_2_10_46_1","volume-title":"B\u00f8rne\u2010og ungdomspsykiatri","author":"Per Hove Thomsen AMS","year":"2012"}],"container-title":["Acta Psychiatrica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acps.13641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T03:24:45Z","timestamp":1705721085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acps.13641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,10]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/acps.13641"],"URL":"https:\/\/doi.org\/10.1111\/acps.13641","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ACPS.13641\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13641\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13641\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13641\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ACPS.13641\/v1\/review1","asserted-by":"object"}]},"ISSN":["0001-690X","1600-0447"],"issn-type":[{"value":"0001-690X","type":"print"},{"value":"1600-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,10]]},"assertion":[{"value":"2023-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}