{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:41:58Z","timestamp":1790854918713,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100018375","name":"Fondation FondaMental","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Metabolic syndrome (MetS) is a cluster of components including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is highly prevalent in individuals with bipolar disorders (BD) with an estimated global rate of 32.6%. Longitudinal data on incident MetS in BD are scarce and based on small sample size. The objectives of this study were to estimate the incidence of MetS in a large longitudinal cohort of 1521 individuals with BD and to identify clinical and biological predictors of incident MetS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were recruited from the FondaMental Advanced Center of Expertise for Bipolar Disorder (FACE\u2010BD) cohort and followed\u2010up for 3\u2009years. MetS was defined according to the International Diabetes Federation criteria. Individuals without MetS at baseline but with MetS during follow\u2010up were considered as having incident MetS. A logistic regression model was performed to estimate the adjusted odds ratio and its corresponding 95% confidence interval (CI) for an association between each factor and incident MetS during follow\u2010up. We applied inverse probability\u2010of\u2010censoring weighting method to minimize selection bias due to loss during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among individuals without MetS at baseline (<jats:italic>n<\/jats:italic>\u2009=\u20091521), 19.3% developed MetS during follow\u2010up. Multivariable analyses showed that incident MetS during follow\u2010up was significantly associated with male sex (OR\u2009=\u20092.2, 95% CI\u2009=\u20091.7\u20133.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), older age (OR\u2009=\u20092.14, 95% CI\u2009=\u20091.40\u20133.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.0004), presence of a mood recurrence during follow\u2010up (OR\u2009=\u20091.91, 95% CI\u2009=\u20091.22\u20133.00, <jats:italic>p<\/jats:italic>\u2009=\u20090.0049), prolonged exposure to second\u2010generation antipsychotics (OR\u2009=\u20091.56, 95% CI\u2009=\u20090.99, 2.45, <jats:italic>p<\/jats:italic>\u2009=\u20090.0534), smoking status at baseline (OR\u2009=\u20091.30, 95% CI\u2009=\u20091.00\u20131.68), lifetime alcohol use disorders (OR\u2009=\u20091.33, 95% CI\u2009=\u20090.98\u20131.79), and baseline sleep disturbances (OR\u2009=\u20091.04, 95% CI\u2009=\u20091.00\u20131.08), independently of the associations observed for baseline MetS components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a high incidence of MetS during a 3\u2009years follow\u2010up (19.3%) in individuals with BD. Identification of predictive factors should help the development of early interventions to prevent or treat early MetS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13655","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T05:49:15Z","timestamp":1706161755000},"page":"207-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Incidence and predictors of metabolic syndrome onset in individuals with bipolar disorders: A longitudinal study from the <scp>FACE\u2010BD<\/scp> cohort"],"prefix":"10.1111","volume":"149","author":[{"given":"O.","family":"Godin","sequence":"first","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"INSERM U955, IMRB, Translational NeuroPsychiatry Laboratory, Universit\u00e9 Paris Est Cr\u00e9teil  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Oli\u00e9","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"Department of Emergency Psychiatry and Acute Care IGF, University of Montpellier, CNRS, INSERM, CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3249-2030","authenticated-orcid":false,"given":"G.","family":"Fond","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"AP\u2010HM, Academic Department of Psychiatry, Resistant Depression Expert Center (FondaMental Foundation), CHU La Conception Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Aouizerate","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"Centre Hospitalier Charles Perrens, P\u00f4le de Psychiatrie G\u00e9n\u00e9rale et Universitaire, Laboratoire NutriNeuro (UMR INRAE 1286) Universit\u00e9 de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Aubin","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"P\u00f4le de Psychiatrie, Centre Hospitalier Princesse Grace  Monaco France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3660-6640","authenticated-orcid":false,"given":"F.","family":"Bellivier","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"INSERM UMR\u2010S 1144, Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie OTeN Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"H\u00f4pital Fernand Widal, D\u00e9partement de Psychiatrie et de M\u00e9decine Addictologique AP\u2010HP, Groupe Hospitalo\u2010Universitaire AP\u2010HP Nord, DMU Neurosciences  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Belzeaux","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"University of Montpellier &amp; Department of Psychiatry, CHU de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Courtet","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"Department of Emergency Psychiatry and Acute Care IGF, University of Montpellier, CNRS, INSERM, CHU Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dubertret","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"AHPH, Departement de Psychiatrie Hopital Louis Mourier  Colombes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Haffen","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"UR 481 LINC, Service de Psychiatrie de l'Adulte, CIC\u20101431 INSERM, CHU de Besan\u00e7on Universit\u00e9 de Franche\u2010Comt\u00e9  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lefrere","sequence":"additional","affiliation":[{"name":"Fondation FondaMental  Cr\u00e9teil France"},{"name":"P\u00f4le de Psychiatrie, Assistance Publique H\u00f4pitaux de Marseille, Marseille, France; INT\u2010UMR7289 CNRS Aix\u2010Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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