{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:54:58Z","timestamp":1785524098442,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R279\u20102018\u20101145"],"award-info":[{"award-number":["R279\u20102018\u20101145"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term studies comparing nonresponse to antidepressants for major depressive disorder (MDD) are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To present systematic population\u2010based nation\u2010wide register data on comparative 2\u2010year non\u2010response within six antidepressant drug classes and 17 different antidepressants in patients with MDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study included all 106,920 patients in Denmark with a first main index diagnosis of MDD at a psychiatric hospital inpatient or outpatient contact and who subsequently had a purchase of an antidepressant in the period from 1995 to 2018. Non\u2010response to first antidepressant within a 2\u2010year study period was defined as switch to or add\u2010on of another antidepressant, antipsychotic medication, lithium, or hospitalization. Analyses emulated a targeted trial in populations standardized according to age, sex, socioeconomic status, and comorbidity with psychiatric and physical disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with sertraline, there was no difference for citalopram (RR: 1.00 [95% CI: 0.98\u20131.02]) but fluoxetine (1.13 [95% CI: 1.10\u20131.17]), paroxetine (1.06 [95% CI: 1.01\u20131.10]) and escitalopram (1.22 [95% CI: 1.18\u20131.25]) were associated with higher risk ratio of non\u2010responses. Within selective noradrenaline reuptake inhibitors, sertraline outperformed reboxetine; within serotonin\u2010norepinephrine reuptake inhibitors, venlafaxine outperformed duloxetine; within <jats:italic>noradrenergic and specific serotonergic antidepressants<\/jats:italic>, mirtazapine outperformed mianserin and within the class of other antidepressants, sertraline outperformed agomelatine and vortioxetine. Within tricyclic antidepressants, compared to amitriptyline, nortriptyline, dosulepin, and clomipramine had higher non\u2010response, whereas there was no difference for imipramine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These analyses emulating a randomized trial of \u201creal world\u201d observational register\u2010based data show that 2\u2010year long\u2010term non\u2010responses to some antidepressants within six different drug classes are increased over others.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acps.13673","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T03:56:41Z","timestamp":1708487801000},"page":"378-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparative responses to 17 different antidepressants in major depressive disorder: Results from a 2\u2010year long\u2010term nation\u2010wide population\u2010based study emulating a randomized trial"],"prefix":"10.1111","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9377-9436","authenticated-orcid":false,"given":"Lars Vedel","family":"Kessing","sequence":"first","affiliation":[{"name":"Copenhagen Affective disorder Research Center (CADIC) Psychiatric Center Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Christoffer","family":"Ziersen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik M\u00f8lkj\u00e6r","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gerds","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esben","family":"Budtz\u2010J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(17)32802\u20107"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010027574"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.1.5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40501-015-0047-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12623"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.03.024"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200216110-00001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv254"},{"key":"e_1_2_11_10_1","unstructured":"MaligC.The Civil Registration System in Denmark. 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