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We conducted an external validation of the psychosis metabolic risk calculator (PsyMetRiC), a cardiometabolic risk prediction tool developed in the UK and tailored for young people with psychosis. We compared the predictive accuracy and clinical usefulness of PsyMetRiC and a general population\u2010based risk prediction tool for type 2 diabetes, the Finnish Diabetes Risk Score (FINDRISC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included first\u2010episode psychosis and ultra\u2010high\u2010risk for psychosis patients without metabolic syndrome aged 18\u201335\u2009years from the Helsinki Early Psychosis and Turku Early Psychosis Study cohorts. We tested two versions of PsyMetRiC: the full model including age, sex, ethnicity, body\u2010mass index, smoking status, prescription of metabolically\u2010active antipsychotic medication, high\u2010density lipoprotein, and triglyceride concentrations, and the partial\u2010model excluding biochemical predictors, and the simplified FINDRISC including BMI, sex, systolic blood pressure, and fasting glucose. Discrimination, calibration, and decision curve analyses were used to assess the predictive performance and clinical usefulness of both PsyMetRiC and FINDRISC. We performed a site\u2010specific re\u2010calibration of PsyMetRiC (PsyMetRiC\u2010Fi).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study sample consisted of 278 individuals (all White European ethnicity, 58.6% male, mean age 24.8\u2009years, 37.8% smoking, mean BMI 23.5). Discrimination was marginally better in the PsyMetRiC full model (\n                      <jats:italic>C<\/jats:italic>\n                      \u2009=\u20090.72, 95% CI, 0.59\u20130.82) compared with partial model (\n                      <jats:italic>C<\/jats:italic>\n                      \u2009=\u20090.70, 95% CI 0.59\u20130.80) or FINDRISC (\n                      <jats:italic>C<\/jats:italic>\n                      \u2009=\u20090.63, 95% CI 0.54\u20130.71). Calibration plots displayed evidence of minor miscalibration for PsyMetRiC, which corrected following recalibration. Miscalibration was more pronounced for FINDRISC. Decision curve analysis showed that PsyMetRiC offers likely clinical usefulness in improving cardiometabolic risk management in early psychosis compared with giving everyone or no one an intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PsyMetRiC has utility in predicting cardiometabolic risk in Finnish patients with early psychosis. It has better discriminatory accuracy and offers more accurate risk prediction compared to other available strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13752","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T21:09:27Z","timestamp":1724965767000},"page":"56-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Psychosis metabolic risk calculator (\n                    <scp>PsyMetRiC<\/scp>\n                    ) in early psychosis: External validation study in\n                    <scp>Finland<\/scp>"],"prefix":"10.1111","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-7382","authenticated-orcid":false,"given":"Jaakko","family":"Kein\u00e4nen","sequence":"first","affiliation":[{"name":"Mental Health Team, Department of Public Health and Welfare Finnish Institute for Health and Welfare  Helsinki Finland"},{"name":"Department of Psychiatry University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saana","family":"Eskelinen","sequence":"additional","affiliation":[{"name":"Mental Health Team, Department of Public Health and Welfare Finnish Institute for Health and Welfare  Helsinki Finland"},{"name":"Department of Psychiatry University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"From","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Laurikainen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmo","family":"Hietala","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham K.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge UK"},{"name":"Cambridgeshire and Peterborough NHS Foundation Trust  Fulbourn UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Suvisaari","sequence":"additional","affiliation":[{"name":"Mental Health Team, Department of Public Health and Welfare Finnish Institute for Health and Welfare  Helsinki Finland"},{"name":"The Finnish Medical Society Duodecim  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge UK"},{"name":"Cambridgeshire and Peterborough NHS Foundation Trust  Fulbourn UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(23)00058\u20105"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2051\u20105545.2011.tb00014.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)32316\u20105"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.5164"},{"key":"e_1_2_11_6_1","unstructured":"PerryB HoltR Chew\u2010GrahamC et al.Update (with acknowledgement to the late Helen Lester for her contribution to the original 2012 version) positive cardiometabolic health resource: an intervention framework for people experiencing psychosis and schizophrenia. 2023 update. 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