{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:59:31Z","timestamp":1793289571989,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H23\u2010iyaku\u2010ippan\u2010006"],"award-info":[{"award-number":["H23\u2010iyaku\u2010ippan\u2010006"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K16070"],"award-info":[{"award-number":["20K16070"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Psychiatr Scand"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This nested case\u2013control study used a large Japanese administrative database. Pregnancy onset and outcomes were estimated using previously reported algorithms, classifying cases as women becoming pregnant between 2013 and 2022 and ending in a miscarriage. Controls were randomly selected from the entire pregnancy cohort by risk\u2010set sampling with replacement and were individually matched to the cases (3:1). The association between exposure to atypical antipsychotics and risk of miscarriage was assessed using conditional logistic regression adjusted for confounders. The association between benzodiazepine exposure and the risk of miscarriage was assessed as a positive control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the cohort, 44,118 patients were matched with 132,317 controls. The mean ages (standard deviations) of the case and control groups were 33.3 (5.7) and 33.2 (5.5) years, respectively. The prevalence of atypical antipsychotics was 0.5% in both groups. Aripiprazole is an individual antipsychotic with the highest prescription prevalence. The adjusted odds ratios (aOR) for miscarriage were 0.966 (95% confidence interval [CI], 0.796\u20131.173) for atypical antipsychotics and 0.998 (0.784\u20131.269) for aripiprazole. A higher aOR (1.431, 95% CI 1.303\u20131.573) suggested an association with benzodiazepines. A sensitivity analysis that limited the population to women diagnosed with schizophrenia alone did not suggest an association between atypical antipsychotics and the risk of miscarriage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of this study do not suggest an association between exposure to atypical antipsychotics during pregnancy and the risk of miscarriage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.13755","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T07:11:03Z","timestamp":1725520263000},"page":"562-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage"],"prefix":"10.1111","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-368X","authenticated-orcid":false,"given":"Tomofumi","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Laboratory of Biomolecule and Pathophysiological Chemistry, Graduate School of Pharmaceutical Sciences Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Sakai","sequence":"additional","affiliation":[{"name":"Drug Informatics, Faculty of Pharmacy Meijo University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Iwama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine Tohoku University  Sendai Japan"},{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Obara","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Morishita","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiko","family":"Adomi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi","family":"Noda","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"},{"name":"Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization Tohoku University  Sendai Japan"},{"name":"Department of Pharmaceutical Sciences Tohoku University Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Ishikuro","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"},{"name":"Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saya","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Nishigori","sequence":"additional","affiliation":[{"name":"Department of Development and Environmental Medicine, Fukushima Medical Center for Children and Women, Graduate School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"},{"name":"Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization Tohoku University  Sendai Japan"},{"name":"International Research Institute of Disaster Science Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariyasu","family":"Mano","sequence":"additional","affiliation":[{"name":"Laboratory of Biomolecule and Pathophysiological Chemistry, Graduate School of Pharmaceutical Sciences Tohoku University  Sendai Japan"},{"name":"Department of Pharmaceutical Sciences Tohoku University Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Obara","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"},{"name":"Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization Tohoku University  Sendai Japan"},{"name":"Department of Pharmaceutical Sciences Tohoku University Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Japanese Society of Neuropsychopharmacology Japanese Society of Clinical Neuropsychopharmacology.Guideline for pharmacological therapy of schizophrenia 2022 (in Japanese). 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