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Mechanisms that contribute to\n                      <jats:styled-content style=\"fixed-case\">RGC<\/jats:styled-content>\n                      death include some of the same mechanisms involved in bipolar disorders (BD) and are the same mechanisms which are targeted by lithium (Li). We conducted a pharmacoepidemiological, population study in Denmark testing the links between Li prescriptions and risk of glaucoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>A nationwide, register\u2010based historical, prospective cohort study of participants who were alive and over the age of 18 between January 1, 1996 and December 31, 2019. Participants were followed from the start of study until censoring or glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Results<\/jats:title>\n                    <jats:p>\n                      A total of 7,683,398 individuals (51.3% females) contributing 121,366,461 person\u2010years were included in the study. In the general population, Li exposure was associated with developing glaucoma (HR\u2009=\u20091.10, 95% CI\u2009=\u20091.02\u20131.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), but this association was not present in the population with BD (HR\u2009=\u20091.07, 95% CI\u2009=\u20090.93\u20131.22,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.34). In the cumulative dosage analyses of the entire population, people with no Li prescription (HR\u2009=\u20090.78 95% CI\u2009=\u20090.66\u20130.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and between 365 defined daily doses (DDDs) and 5\u2009\u00d7\u2009365 DDDs of Li showed significantly reduced risk of glaucoma, relative to at least one prescription (HR\u2009=\u20090.79, 95% CI\u2009=\u20090.64\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      BDs as indexed by Li prescription are associated with a greater risk of glaucoma. This is in keeping with generally increased rates of medical comorbidities in\n                      <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\n                      . While there was no clear dose\u2013response relationship, some of the higher cumulative exposures to Li might be protective relative to a single prescription.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acps.70010","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T02:39:30Z","timestamp":1751596770000},"page":"308-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Does Lithium Lower the Risk of Glaucoma\u2014A Danish Nationwide Study"],"prefix":"10.1111","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-8458","authenticated-orcid":false,"given":"Tomas","family":"Hajek","sequence":"first","affiliation":[{"name":"Department of Psychiatry Dalhousie University  Halifax Nova Scotia 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